Eurasian Journal of Medical and Natural Sciences 4-jild 2-son (2024) · 383–384-betlar

THE EFFECTS OF 14-BENZOYLKARAKOLINE ON CONTRACTIVE ACTIVITY OF RAT AORTA SMOOTH MUSCLE CELLS

Mirzayeva, Yu.T., Zaripov, A.A., Abrayeva, Z.Ch.

DOI: 10.5281/zenodo.10684055 · Manbada o'qish →

Annotatsiya

It was investigated how 14-benzoylkarakoline affected the rat aortic smooth muscle cells' ability to contract. According to the results, rat aorta preparations that had been constricted by the beta-adrenergic receptor agonist phenylephrine are successfully relaxed by 14-O-BK. It can be deduced that the relaxant effect of the studied alkaloid is caused by the suppression of the transport of Ca2+ ions at the SR level in light of the fact that the contractions induced by this antagonist are primarily caused by the activation of the release of Ca2+ ions from the SR through IP3R.

smooth muscles, sarkoplazmic reticulum, aorta, phenylephrine, Ca2 channel, 14-benzoylkarakoline.

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