Eurasian Journal of Medical and Natural Sciences 5-jild 1-son (2025) · 56–68-betlar

EFFECTS OF ADRENALECTOMY ON THE GUT MICROBIOME AND HYPERTHERMIA INDUCED BY MDMA

Usanova, Saodat

DOI: 10.5281/zenodo.14642828 · Manbada o'qish → · PDF (manba serverida)

Annotatsiya

The widespread use of the stimulant drug 3,4-methylenedioxymethamphetamine (MDMA), commonly referred to as Ecstasy, Molly, or X, has been associated with life-threatening hyperthermia in both humans and animal models. This study aimed to explore the role of the gut-adrenal axis in MDMA-induced hyperthermia by examining the effects of acute exogenous supplementation with norepinephrine (NE) or corticosterone (CORT) in adrenalectomized (ADX) rats following MDMA administration.

Adrenalectomy, gut microbiome, MDMA, hyperthermia, sympatho-adrenal axis, corticosterone, norepinephrine, phenylethylamine, microbiome diversity, gut-brain axis, thermoregulation, microbiota modulation, 16S rRNA sequencing.

Metadata manbasi: jurnal OAI-PMH arxivi · Sindex to'liq matnni saqlamaydi, manbaga havola beradi.