Eurasian Journal of Medical and Natural Sciences 5-jild 10-son (2025) · 92–102-betlar

STUDY OF THE ANTI-ULCER ACTIVITY OF A PHYTOCOMPETENT WITH ADAPTOGENIC PROPERTIES

Зайниддинова, Дилдора, Султанова, Рано, Азаматов, Азизбек

DOI: 10.5281/zenodo.17336608 · Manbada o'qish →

Annotatsiya

In this article, the acute toxicological properties and local analgesic (anesthetic) activity of tannins isolated from plants Salvia Sclarea L. (sage) and Matricaria Chamomilla L. (chamomile) were studied on an experimental animal model (mice). The acute toxicity index was studied by oral administration (per os) of the substance to animals in various doses (100.0–15800.0 mg/kg). The experimental results showed that the acute toxicity index, estimated by LD₅₀, was 14600.3 mg/kg with oral administration of tannin, which confirms the classification of this substance as low-toxic. The anesthetic activity was studied using the methods of Rainier, as well as Bulbring and Vida. In experiments conducted using the Rainier method with 0.5% tannin solution, the time of onset of anesthesia was 3.7±0.3 minutes, the time of complete anesthesia was 12.1±0.7 minutes, and the total duration was 15.8 ± 0.9 minutes. The results of the Bulbring and Vida method confirmed that the substance has a dose-dependent pain-reducing effect; in this model, the maximum effect of 0.5% tannin solution was also observed. The results of the study show the prospects of introducing tannins of natural origin into medical practice as a low-toxic compound with local analgesic effect.

Salvia Sclarea L., Matricaria Chamomilla L., tannin, acute toxicity, LD₅₀, Rainier method, Bulbring and Vida method, anesthetic activity.Salvia Sclarea L., Matricaria Chamomilla L., дубильное вещество, острая токсичность, LD₅₀, метод Ренье, метод Бульбринга и Вайды, анестетическая активность.

Metadata manbasi: jurnal OAI-PMH arxivi · Sindex to'liq matnni saqlamaydi, manbaga havola beradi.