Eurasian Journal of Medical and Natural Sciences 5-jild 10-son (2025) · 225–244-betlar

Β-LACTAM RESISTANCE IN ENTEROBACTERIACEAE: MOLECULAR MECHANISMS, EPIDEMIOLOGICAL PATTERNS, AND CLINICAL SIGNIFICANCE

Bazarova, Gulnora

DOI: 10.5281/zenodo.17416140 · Manbada o'qish →

Annotatsiya

Members of the Enterobacteriaceae family, although natural constituents of the gut microbiota, are responsible for numerous severe infections, including bloodstream infections. β-lactam antibiotics have long represented the cornerstone of therapeutic management for these infections. However, extensive and often inappropriate use of these agents has led to the emergence and global spread of β-lactam-resistant Enterobacteriaceae. The principal mechanism of resistance involves the production of β-lactam–inactivating enzymes, notably extended-spectrum β-lactamases (ESBLs) and carbapenemases, which confer multidrug resistance and significantly restrict therapeutic options. Consequently, β-lactam resistance is associated with increased drug toxicity, higher mortality rates, and greater healthcare costs. This review summarizes current evidence on the molecular mechanisms and epidemiological trends of β-lactamase-mediated resistance among Enterobacteriaceae, emphasizing its clinical implications and public health impact.

Enterobacteriaceae, β-lactamase, antimicrobial resistance, β-lactam antibiotics, molecular mechanisms.

Metadata manbasi: jurnal OAI-PMH arxivi · Sindex to'liq matnni saqlamaydi, manbaga havola beradi.