Eurasian Journal of Medical and Natural Sciences 5-jild 3-son (2025) · 60–65-betlar

COMPLEX THERAPHY EFFECT IN AUTOIMMUNE DISEASES

Toshnazarova, Nodira

DOI: 10.5281/zenodo.15010079 · Manbada o'qish → · PDF (manba serverida)

Annotatsiya

This comprehensive observational cohort study meticulously evaluated the effectiveness and safety associated with the combination therapy of adalimumab and methotrexate in individuals diagnosed with the debilitating condition known as rheumatoid arthritis (RA). The participants in this investigation were systematically categorized into three distinct groups, each receiving different treatment regimens. The findings revealed that the synergistic combination of adalimumab and methotrexate demonstrated a statistically significant superiority over methotrexate used as a standalone treatment in achieving clinically meaningful responses, specifically measured by ACR20, ACR50, and ACR70, during a rigorous nine-month treatment period. In this context, Group IB, which was administered a higher dosage of methotrexate, displayed marginally improved rates of clinical improvement compared to Group IA; however, it is worth noting that the difference between these two groups did not reach statistical significance.

Rheumatoid arthritis, adalimumab, methotrexate, observational study.

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