Eurasian Journal of Medical and Natural Sciences 5-jild 4-son (2025) · 208–215-betlar

LEUKOTRIENE RECEPTORS, THEIR IMPORTANCE IN MEDICAL PRACTICE AND THE DRUGS ACTING ON THEM

Rashidov, Sokhib, Yakubova, Nigora, Shaxkhmurova, Madina, Bozorov, Akmal, Abdurasulov, Abdusamad

DOI: 10.5281/zenodo.15267951 · Manbada o'qish →

Annotatsiya

Strong lipid mediators, leukotrienes (LTs), such as cysteinyl LTs (CysLTs) and LTB4, play a key role in the pathogenesis of asthma symptoms. There are at least two known receptor subtypes for CysLTs: CysLT1 and CysLT2. The activation of the CysLT1 receptor mediates the majority of the pathophysiological consequences of CysLTs in asthma, such as increased airway smooth muscle activity, microvascular permeability, and airway mucus secretion. Asthma exacerbations, severe asthma, and airway hyperresponsiveness may all be influenced by LTB4. CysLT1 receptor antagonists can be administered orally as monotherapy in patients with persistent mild asthma, despite the fact that they are typically less efficacious than inhaled glucocorticoids.

Inhaled glucocorticoids, airway inflammation, leukotrienes, cysteinyl-leukotrienes, leukotriene B4, leukotriene receptor antagonists, asthma.

Metadata manbasi: jurnal OAI-PMH arxivi · Sindex to'liq matnni saqlamaydi, manbaga havola beradi.