Eurasian Journal of Medical and Natural Sciences 6-jild 5-son (2026) · 37–42-betlar

THE ROLE OF AUTOPHAGY IN THE PATHOGENESIS OF TYPE 2 DIABETES AND BIOCHEMICAL CORRECTION OF INTERVAL FASTING

Tursunova, Ravshanoy, Boltayeva, Surayyo

DOI: 10.5281/zenodo.20378190 · Manbada o'qish →

Annotatsiya

Metabolic dysfunction at the cellular level remains a key factor in the pathogenesis of type 2 diabetes mellitus (T2DM) worldwide. This article analyzes the blockade of the autophagy process as a result of excessive activation of the mTOR signaling pathway in conditions of chronic hyperinsulinemia. The study examines the possibilities of activating the AMPK protein and triggering the "metabolic switch" mechanism through the intermittent fasting (16:8) regime. The data show that 16–18 h of fasting biochemically corrects insulin resistance by breaking down amyloid aggregates in beta cells. The results obtained justify the advantages of a cytocentric approach in reducing the pharmacological burden in the control of T2DM and achieving disease remission.

T2DM, autophagy, intermittent fasting, mTOR/AMPK balance, insulin sensitivity, amyloid aggregates, beta-cell regeneration.СД2, аутофагия, прерывистое голодание, баланс mTOR/AMPK, чувствительность к инсулину, амилоидные агрегаты, регенерация бета-клеток.T2DM, autofagiya, interval ochlik, mTOR/AMPK balansi, insulin sensitivity, amiloid agregatlar, beta-hujayralar regeneratsiyasi.

Metadata manbasi: jurnal OAI-PMH arxivi · Sindex to'liq matnni saqlamaydi, manbaga havola beradi.