Eurasian Journal of Medical and Natural Sciences 6-jild 6-son (2026) · 54–66-betlar

EXPERT EVALUATION METHODOLOGY FOR GRADATION OF THE ANTHELMINTHIC MEDICINES ASSORTMENT ON THE PHARMACEUTICAL MARKET OF THE REPUBLIC OF UZBEKISTAN

Shakirov, Mokhirjan, Umarova, Shakhnoz, Rakhimov, Abror

DOI: 10.5281/zenodo.20678108 · Manbada o'qish →

Annotatsiya

This study presents a structured, mathematically grounded methodology for the systematic gradation and clinical prioritization of anthelminthic medicines available on the pharmaceutical market of the Republic of Uzbekistan. A purposively recruited expert panel of 68 highly qualified parasitologists and infectious disease specialists evaluated eight active pharmaceutical ingredients (INNs) using a weighted 5-point clinical utility scale and an extended 10-point multi-criteria assessment across eight primary consumer properties. Individual expert competence coefficients (Sp) were calculated and applied as weighting factors to minimize subjective bias. Consensus levels were quantified using the coefficient of variation (CV). Mathematical modeling results classified Albendazole and Mebendazole into Group 1 — 'Favorable Market Conjuncture' (CV ≤25%; composite index ≈0.87), establishing them as obligatory first-line therapeutic agents. Pyrantel, Niclosamide, and the Albendazole + Ivermectin combination were categorized into Group 2 ('Risk Group'), warranting epidemiology-guided procurement. Levamisole, Carbendazim, and the Albendazole + Levamisole combination were assigned to Group 3 — 'Unfavorable Market Conjuncture' (CV = 56–78%), with procurement strongly discouraged. 

Anthelminthic medicines; expert evaluation; competence coefficient; coefficient of variation; composite index; pharmaceutical market gradation; Uzbekistan.

Metadata manbasi: jurnal OAI-PMH arxivi · Sindex to'liq matnni saqlamaydi, manbaga havola beradi.