Eurasian Journal of Academic Research 6-jild 4-son (2026) · 33–40-betlar

DEVELOPMENT AND STANDARDIZATION OF A SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY TABLET BASED ON WORMWOOD (ARTEMISIA ABSINTHIUM) POLLEN

Абдугофурова, Мадинахон, Азимова, Наргиза

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Annotatsiya

This study presents the results of the development and standardization of a tablet dosage form intended for sublingual allergen-specific immunotherapy (SLIT) based on wormwood (Artemisia absinthium) pollen. The key quality attributes of the formulation were evaluated, including total nitrogen content as an indirect indicator of the protein fraction, solubility, dosage uniformity, and stability. The findings demonstrated that the total nitrogen content was 0.145%, confirming the presence of biologically active protein components. The tablets exhibited satisfactory solubility and met the requirements for dosage uniformity at a mass of 0.3 g. Stability studies showed that the main quality parameters remained unchanged throughout the observation period. The obtained results indicate the potential of the developed dosage form and support its further standardization.

SLIT, wormwood, Artemisia absinthium, total nitrogen, protein, solubility, dosage uniformity, stability, pharmaceutical development.СЛИТ, полынь горькая, Artemisia absinthium, общий азот, белок, растворимость, однородность дозирования, стабильность, фармацевтическая разработка.

Metadata manbasi: jurnal OAI-PMH arxivi · Sindex to'liq matnni saqlamaydi, manbaga havola beradi.