Бюллетень педагогов Нового Узбекистана 4-jild 6-son (2026) · 127–132-betlar

COMPARATIVE ANALYSIS OF GLYCYRRHETINIC ACID DERIVATIVES BASED ON THEIR ACTIVITY INDICATORS: A CROSS-STUDY EVALUATION OF CYTOTOXICITY IN STANDARD CANCER CELL LINES

Xolboeva, Madina

DOI: 10.5281/zenodo.20962745 · Manbada o'qish → · PDF (manba serverida)

Annotatsiya

Glycyrrhetinic acid (GA, 18 β-glycyrrhetinic acid) is a pentacyclic triterpenoid scaffold of considerable interest in anticancer drug discovery because chemical modification of its hydroxyl, carboxyl, and ring A functionalities can markedly alter cytotoxic potency, selectivity, and mechanism of action. The aim of the present article was to conduct a comparative analysis of glycyrrhetinic acid derivatives on the basis of activity indicators reported in original experimental studies and to identify the most promising structural series across different standard cancer cell lines. Five peer-reviewed papers with real and verifiable DOI numbers were selected: Molecules (2016), Bioorganic Chemistry (2019), Biological and Pharmaceutical Bulletin (2020), Bioorganic Chemistry (2020), and Molecules (2023). The comparison focused on derivative class, cancer cell-line spectrum, IC50 values, selectivity toward normal cells, apoptosis-related findings, oxidative stress markers, and preliminary structure–activity relationship (SAR) trends

This work was designed as an analytical comparative review based exclusively on original experimental publications.

Metadata manbasi: jurnal OAI-PMH arxivi · Sindex to'liq matnni saqlamaydi, manbaga havola beradi.