Eurasian Journal of Academic Research 2-jild 11-son (2022) · 1027–1033-betlar

TOXICOLOGICAL CHARACTERISTICS OF VINCANIN HYDROCHLORIDE AND ITS DERIVATIVES IN AN EXPERIMENTAL CONDITION

Mirzаev, Yu.R., Khamraev, T.T., Ruzimov, E.M., Adizov, Sh.M., Abduazimov, B.B., Khandamov, B.N., Elmurodov, B.J., Yuldashev, P.H.

DOI: 10.5281/zenodo.7244593 · Manbada o'qish → · PDF (manba serverida)

Annotatsiya

This presented research paper presents the results of studying the acute toxicity of vincan and its derivatives using various methods of administration isolated from the Vinca erecta plant, As a result of experimental studies, it was determined that vincanin hydrochloride with oral administration is class III, that is highly toxic, according to the classification of acute toxicity of substances and with subcutaneous and intravenous administration II, that is substances that are highly toxic have been recognized as belonging to the class. While its derivatives with oral and subcutaneous administration belong to the IV, that islow-toxic class in accordance with the classification of acute toxicity of substances with intravenous administration, it was found that both substances belong to class II, that is substances that are highly toxic.

Vinca erecta, Vincanin hydrochloride, pyrosaline hydrochloride, pyrosaline iodine methylate, acute toxicity, LD50, oral, subcutaneous, intravenous

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