Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali 3-jild 2-son (2022)
FEATURES OF THYROID DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH CARDIOMETABOLIC SYNDROME
Шодикулова Гуландом Зикрияевна, Шоназарова Нодира Худойбердиевна
Annotatsiya
The thyroid gland (TG) is an iodine-producing (thyroid) hormone-producing gland that regulates the secretion of other hormones. Thyroid hormones affect the metabolism of all organs in the body and are involved in the growth and formation of all organs and tissues. First of all, it stimulates heat generation, increases the absorption of oxygen by tissues, enhances oxidative processes in the body. In a physiological dose, thyroid hormones stimulate the synthesis of intracellular proteins, the excess of which accelerates the process of dissimilation. Rheumatoid arthritis (RA) is a widespread (1% of the world's population) autoimmune disease characterized by symmetrical erosive arthritis (synovitis) and damage to organs other than the joints. Manifestations of RA are: pain in the joints, dysfunction and progressive deformity of the joints, irreversible changes in the internal organs, leading to early disability (a third of patients become disabled within 20 years from the onset of the disease) and a decrease in life expectancy of patients (on average 5-15 years). It was reported that goiter, hypothyroidism, chronic adrenal insufficiency and other pathologies of the endocrine glands are more common in patients with RA. Thyroid hormones increase the activity of metabolic processes, enhance lipogenesis, increase glucose uptake by adipose and muscle tissue, activate gluconeogenesis and glycogenolysis.
Щитовидная железа, ревматоидный артрит, гипотиреозThyroid gland, rheumatoid arthritis, hypothyroidismqalqonsimon bez, revmatoid artrit, gipotiroidizm
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