O‘zbekiston кardiologiyasi 3-jild 1-son (2026) · 4-15-betlar

The role of PITX2 rs6817105 and KCNN3 rs13376333 polymorphisms in the risk of atrial fibrillation complicating arterial hypertension.

Mashkurova, Zaringiz, Abdullaeva, Guzal, Zakirova, Darya, Rajabova, Gulrux, Xamidullayeva, Gulnoza, Abdullaev, Alisher, Rozibaev, Bekzod, Машкурова, З, Абдуллаева, Г, Закирова, Д, Раджабова, Г, Хамидуллаева, Г, Абдуллаев, А, Розибаев, Б, Mashkurova, Zaringiz, Abdullayeva, Guzal, Zakirova, Darya, Rajabova, Gulrux, Xamidullayeva, Gulnoza, Abdullayev, Alisher, Rozibayev, Bekzod

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Annotatsiya

Aim. To determine the association between polymorphisms of the PITX2 (rs6817105) and KCNN3 (rs13376333) genes and the development of atrial fibrillation (AF) in patients with arterial hypertension (AH) in the Uzbek population. Materials and methods. The study included 154 patients with AH. Among them, paroxysmal AF was initially diagnosed in 21 patients (13.64%), persistent AF in 44 patients (28.57%), and permanent AF in 89 patients (57.79%). At the beginning of the study, the mean age of patients with AH and AF was 64.1±10.35 years. The control group consisted of AH patients without AF (n=91), with a mean age of 56.03±12.18 years. Clinical and instrumental examinations, including ECG, echocardiography, and Holter monitoring, were performed. Molecular genetic analysis of isolated DNA was carried out using real-time PCR. The association of polymorphisms with AF was assessed using logistic regression analysis and various inheritance models. Statistical analysis was performed using Statistica 10.0 and SNPassoc (R) software. Results. The study revealed statistically significant associations between the risk of atrial fibrillation development and the PITX2 gene rs6817105 polymorphism as well as the KCNN3 gene rs13376333 polymorphism in Uzbek patients with arterial hypertension. The PITX2 rs6817105 polymorphism showed a strong association with atrial fibrillation: carriage of the minor C allele increased the risk of AF development 2.76-fold under the log-additive inheritance model (OR = 2.76; p = 3.27×10⁻⁷). The KCNN3 rs13376333 polymorphism also demonstrated a significant association with AF. The C allele was significantly more frequent in patients with rhythm disorders and increased the risk of AF development under the log-additive model (OR = 1.63; p = 0.020). Conclusion. For the first time, an association between the PITX2 gene rs6817105 polymorphism and the KCNN3 gene rs13376333 polymorphism with atrial fibrillation has been identified in AH patients of the Uzbek population. These findings confirm the importance of these genetic markers in the pathogenesis of atrial fibrillation complicated by arterial hypertension and emphasize the relevance of genetic testing in this group of patients.

Arterial hypertensionatrial fibrillationPITX2 gene rs6817105 polymorphismKCNN3 gene rs13376333 polymorphismАртериальная гипертензияфибрилляция предсердийполиморфизм rs6817105 гена PITX2полиморфизм rs13376333 гена KCNN3Arterial gipertenziyabo‘lmachalar fibrillyatsiyasi

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Iqtibos olish

APA 7 
Mashkurova, Zaringiz, Abdullaeva, Guzal, Zakirova, Darya, Rajabova, Gulrux, Xamidullayeva, Gulnoza, Abdullaev, Alisher, Rozibaev, Bekzod, Машкурова, З, Абдуллаева, Г, Закирова, Д, Раджабова, Г, Хамидуллаева, Г, Абдуллаев, А, Розибаев, Б, Mashkurova, Zaringiz, Abdullayeva, Guzal, Zakirova, Darya, Rajabova, Gulrux, Xamidullayeva, Gulnoza, … Rozibayev, Bekzod (2026). The role of PITX2 rs6817105 and KCNN3 rs13376333 polymorphisms in the risk of atrial fibrillation complicating arterial hypertension.. O‘zbekiston кardiologiyasi, 3(1), 4-15.
GOST R 7.0.5 
Mashkurova, Zaringiz, Abdullaeva, Guzal, Zakirova, Darya, Rajabova, Gulrux, Xamidullayeva, Gulnoza, Abdullaev, Alisher, Rozibaev, Bekzod, Машкурова, З, Абдуллаева, Г, Закирова, Д, Раджабова, Г, Хамидуллаева, Г, Абдуллаев, А, Розибаев, Б, Mashkurova, Zaringiz, Abdullayeva, Guzal, Zakirova, Darya, Rajabova, Gulrux, Xamidullayeva, Gulnoza, Abdullayev, Alisher, Rozibayev, Bekzod The role of PITX2 rs6817105 and KCNN3 rs13376333 polymorphisms in the risk of atrial fibrillation complicating arterial hypertension. // O‘zbekiston кardiologiyasi. 2026. Т. 3. № 1. С. 4-15.
BibTeX 
@article{zaringiz2026,
  author  = {Mashkurova, Zaringiz and Abdullaeva, Guzal and Zakirova, Darya and Rajabova, Gulrux and Xamidullayeva, Gulnoza and Abdullaev, Alisher and Rozibaev, Bekzod and Машкурова, З and Абдуллаева, Г and Закирова, Д and Раджабова, Г and Хамидуллаева, Г and Абдуллаев, А and Розибаев, Б and Mashkurova, Zaringiz and Abdullayeva, Guzal and Zakirova, Darya and Rajabova, Gulrux and Xamidullayeva, Gulnoza and Abdullayev, Alisher and Rozibayev, Bekzod},
  title   = {The role of PITX2 rs6817105 and KCNN3 rs13376333 polymorphisms in the risk of atrial fibrillation complicating arterial hypertension.},
  journal = {O‘zbekiston кardiologiyasi},
  year    = {2026},
  volume  = {3},
  number  = {1},
  pages   = {4-15}
}
RIS 
TY  - JOUR
AU  - Mashkurova, Zaringiz
AU  - Abdullaeva, Guzal
AU  - Zakirova, Darya
AU  - Rajabova, Gulrux
AU  - Xamidullayeva, Gulnoza
AU  - Abdullaev, Alisher
AU  - Rozibaev, Bekzod
AU  - Машкурова, З
AU  - Абдуллаева, Г
AU  - Закирова, Д
AU  - Раджабова, Г
AU  - Хамидуллаева, Г
AU  - Абдуллаев, А
AU  - Розибаев, Б
AU  - Mashkurova, Zaringiz
AU  - Abdullayeva, Guzal
AU  - Zakirova, Darya
AU  - Rajabova, Gulrux
AU  - Xamidullayeva, Gulnoza
AU  - Abdullayev, Alisher
AU  - Rozibayev, Bekzod
TI  - The role of PITX2 rs6817105 and KCNN3 rs13376333 polymorphisms in the risk of atrial fibrillation complicating arterial hypertension.
JO  - O‘zbekiston кardiologiyasi
PY  - 2026
VL  - 3
IS  - 1
SP  - 4
EP  - 15
ER  -