Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 10-jild 5-son (2025)

MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX

ШАХАНОВА Шахноза Шавкатовна, МАДАМИНОВА Севарахон Мухаммаджон кизи, ЭСАНКУЛОВА Бустоной Собировна, КАМАЛОВА Барно Зафаровна

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Annotatsiya

The article presents current data on the pathogenesis and morphological characteristics of HPV-associated lesions of the vulva and cervix. The mechanisms of viral DNA integration and expression of oncogenic proteins E6 and E7, leading to dysregulation of the cell cycle and neoplastic transformation of the epithelium, are discussed. Morphological features of intraepithelial neoplasia (CIN, VIN) and the diagnostic value of immunohistochemical markers p16, Ki-67, p53, and E-cadherin are described. The importance of differentiating HPV-dependent and HPV-independent carcinogenic pathways is emphasized. An integrated approach to early diagnosis and prevention of HPV-induced neoplasms of the lower female genital tract is presented.

ВПЧ-инфекция, шейка матки, вульва, неоплазия, p16, Ki-67, патогенез, морфологияHPV infection, cervix, vulva, neoplasia, p16, Ki-67, pathogenesis, morphologyВПЧ инфекцияси, бачадон бўйни, вульва, неоплазия, p16, Ki-67, патогенез, морфология

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Iqtibos olish

APA 7 
ШАХАНОВА Шахноза Шавкатовна, МАДАМИНОВА Севарахон Мухаммаджон кизи, ЭСАНКУЛОВА Бустоной Собировна & КАМАЛОВА Барно Зафаровна (2025). MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5).
GOST R 7.0.5 
ШАХАНОВА Шахноза Шавкатовна, МАДАМИНОВА Севарахон Мухаммаджон кизи, ЭСАНКУЛОВА Бустоной Собировна, КАМАЛОВА Барно Зафаровна MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. 2025. Т. 10. № 5.
BibTeX 
@article{шавкатовна2025,
  author  = {ШАХАНОВА Шахноза Шавкатовна and МАДАМИНОВА Севарахон Мухаммаджон кизи and ЭСАНКУЛОВА Бустоной Собировна and КАМАЛОВА Барно Зафаровна},
  title   = {MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year    = {2025},
  volume  = {10},
  number  = {5}
}
RIS 
TY  - JOUR
AU  - ШАХАНОВА Шахноза Шавкатовна
AU  - МАДАМИНОВА Севарахон Мухаммаджон кизи
AU  - ЭСАНКУЛОВА Бустоной Собировна
AU  - КАМАЛОВА Барно Зафаровна
TI  - MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX
JO  - Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
PY  - 2025
VL  - 10
IS  - 5
ER  -