Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research 5-jild 5-son (2024)
THE ASSOCIATION BETWEEN MELATONIN ADMINISTRATION AND SLEEP QUALITY IN ACUTE ISCHEMIC STROKE PATIENTS
Мусаева Юлдуз Алписовна, Тавмуродова Мафтуна Гайрат кизи, Шокиров Шохнур Шухрат угли
Annotatsiya
Stroke is a leading cause of disability and mortality all over the world. Due to an aging population, the incidence of stroke is rising significantly, which has led to devastating consequences for patients. In addition to traditional risk factors such as age, hypertension, hyperlipidemia, diabetes and atrial fibrillation, sleep disorders, as independent modifiable risk factors for stroke, have been highlighted increasingly. The aim of the study: To assess the association of Melatonin administration during an acute phase of ischemic stroke patients towards sleep quality Materials and methods: This study used a randomized control trial design Subjects participated from the department of Intensive Therapy in Multidisciplinary clinic of Tashkent Medical Academy. Participants are 32 acute ischemic stroke patients. Eligible subjects divided into 2 main groups with simple random sampling method. First group consisted of 16 subjects who received Melatonin, twice daily for 30 days and second group consisted of 16 subjects received placebo, twice daily for 30 days. No major adverse effect was reported during observation. Results: Sleep quality were measured by The Pittsburgh Sleep Quality Index (PSQI) questionaire at day 1 of admission and at day 30 of the study when subjects returned for routine checkup at Neurology clinic for each subject. PSQI global score ≤ 5 indicates good sleep quality while global score > 5 indicates a poor sleep quality. Subjects were mainly male (56,3%), mean age of 59,6 ± 10,8 years. Measurement at day 1 indicated poor sleep quality on both group with PSQI global score 7,9 ± 2,0. Upon completion group who received Melatonin twice daily marked an improvement in PSQI global score from mean score of 7,8 ± 1,7 at day 1 to mean score of 5,1 ± 2,4 at day 30. No remarkable improvement from Placebo group with similar mean score before and after protocol (8,0 ± 2,4 at day 1 vs 6,9 ± 3,1 at day 30). Conclusions: There is an association between melatonin administration and sleep quality of acute ischemic stroke patients.
ишемический инсульт, нарушения сна, мелатонин, стратегии леченияischemic stroke, sleep disorders, melatonin, treatment strategyishemik insult, uyqu buzilishi, melatonin, davolash strategiyasi
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