Жанубий оролбўйи тиббиёт журнали 2-jild 3-son (2026) · 266-274-betlar
THE ROLE OF URINARY BIOMARKERS IN THE PREDICTION OF TUBULOINTERSTITIAL KIDNEY INJURY IN CHILDREN FOLLOWING COVID-19
Gapparova, Guli
Annotatsiya
The COVID-19 pandemic has demonstrated the vulnerability of the kidneys as target organs due to high ACE2 expression in renal tubular epithelial cells. The aim of this study was to develop a diagnostic and prognostic approach for pediatric acute pyelonephritis based on the assessment of urinary biomarkers of kidney injury. A total of 100 children aged 7–17 years with acute pyelonephritis were included and divided into two groups according to previous COVID-19 history, along with 25 clinically healthy children as a control group. All participants underwent urinalysis, and measurement of urinary KIM-1, NGAL, β₂-microglobulin, and L-FABP levels. Children with a history of SARS-CoV-2 infection showed significantly elevated urinary biomarker levels and more pronounced subclinical signs of tubulointerstitial injury, including leukocyturia, microhematuria, proteinuria, as well as reduced titratable acidity and ammonia excretion (p<0.001). These findings indicate predominant tubulointerstitial kidney damage even in the absence of clinical manifestations. Early assessment of urinary biomarkers is essential for timely diagnosis and optimization of patient management.
acute pyelonephritischildrenCOVID-19KIM-1NGAL
Metadata manbasi: jurnal OAI-PMH arxivi · Sindex toʻliq matnni saqlamaydi, manbaga havola beradi.