Товарлар кимёси ва халқ табобати Volume 1 Issue 5 (2022) · pp. 77-93
PREPARATION OF NEW FERROCENE DERIVATIVES OF ARTESUNATE
Abdulloev, Obidjon Sh., Askarov, Ibragim R., Abdulloev, Shakhobidin Kh., Matamirova, Sharifa A.
Abstract
Three new esters of some ferrocenyl-containing alcohols with artesunate were synthesized, the composition and structure of which were analyzed using 1H and 13C NMR spectroscopy. An increase in the proportion of ((1S)-1-ferrocenyl)-ethylartesunate in the racemic mixture of the product to 94.1% compared with the proportion of (1S)-1-ferrocenylethanol equal to 75% in the original racemate shows that the esterification reaction (1R)-1 -ferrocenylethanol with artesunate is more difficult than with another antipode of alcohol.
Артемизининартесунатферроценилметанолферроценилэтанолферроценилметилартесунатферроценилэтилартесунатсинтезспектр ЯМРоптический изомерArtemisinin
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