Товарлар кимёси ва халқ табобати Том 3 № 5 (2024) · с. 79-103
CATALYTIC CYCLIZATION OF ISOMERIC PROP-2-YN-1-IL-2-(NITROPHENOXY) ACETATES AND ORTHO-BROMOPHENYLAZIDE
Makhsumov, Abdukhamit G., Khojimatova, Shakhnoza R.
Аннотация
Propargyl ester of monoiodoacetic acid was synthesized by esterification of monoiodoacetic acid with propargyl alcohol. The resulting monoiodoacetic ester was used for alkylation of isomeric nitrophenols. The 1,3-bipolar cycloaddition reaction of the synthesized isomeric nitrophenoxypropargyl esters with ortho-bromophenyl azide was carried out in the presence of a catalyst. Copper(I) halides were used as catalysts. As a result, 1,4-isomers of 1,2,3-triazole derivatives were synthesized. The structure of the obtained substances was confirmed by IR and NMR spectroscopy.
пропаргиловый эфир монойодуксусной кислотыизомерные нитрофенолы1,2,3-триазолыреакции циклизациипроп-2-ин-1-ил-2-(2-нитрофенокси) ацетатpropargyl ester of monoiodoacetic acidisomeric nitrophenols1,2,3-triazolescyclization reactionsprop-2-yn-1-yl-2-(2-nitrophenoxy) acetate
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