Klinik fanlar yilnomasi 2-tom 3-san (2025)
DYNAMICS OF LIVER FIBROGENESIS MARKERS IN PATIENTS WITH TUBERCULOSIS WITHOUT VIRAL HEPATITIS WITHIN THE FRONT OF TREATMENT
Йитмасова Туҳфа Давлатовна, Облоқулов Абдурашид Рахимович, Усмонов Исомиддин Хайдарович
Annotaciya
While the hepatotoxicity of anti-tuberculosis therapy is well-documented, its direct impact on liver fibrogenesis requires clarification. The aim of this study was to comparatively evaluate the levels of key markers of liver fibrogenesis—collagen types I and IV—in 30 tuberculosis patients without viral hepatitis before and after standard treatment. Serum levels of collagen types I and IV were assessed by ELISA after the 2-month intensive phase of therapy. The results demonstrated a statistically significant increase in the concentration of both collagen types during treatment (p<0.001). These findings indicate that anti-tuberculosis drugs not only cause hepatocyte injury but also activate the initial stages of fibrous tissue formation in the liver. Collagen types I and IV may serve as sensitive non-invasive markers for assessing the fibrogenic potential of anti-tuberculosis therapy and for the early diagnosis of drug-induced liver injury.
tuberculosis, drug-induced liver injury (DILI), hepatotoxicity, liver fibrosis, collagen type I, collagen type IV, fibrogenesis, non-invasive diagnosticsтуберкулез, лекарственное поражение печени, гепатотоксичность, фиброз печени, коллаген I, коллаген IV, фиброгенез, неинвазивная диагностикасил, доридан жигар шикастланиши, гепатотоксиклик, жигар фибрози, коллаген I, коллаген IV, фиброгенез, ноинвазив диагностика
Metadata derekkózi: jurnal OAI-PMH arxivi · Sindex tolıq mátindi saqlamaydı, derekkózge silteme beredi.