Klinik fanlar yilnomasi Volume 2 Issue 4 (2025)
CHARACTERISTICS OF CHANGES IN IMMUNE SYSTEM INDICATORS IN THYROID GLAND DISEASES
Нарзиев Шерали Мухаммадович, Нуралиев Неккадам Абдуллаевич
Abstract
Relevance. Comparative studies of humoral immunity and the cytokine status of the immune system in various thyroid diseases and the study of the relationships between them have not been conducted sufficiently, and those that exist are scattered. Purpose. To determine humoral immunity and cytokine status in thyroid diseases, as well as to assess the relationship between them. Material and methods. Humoral immunity indices in patients' blood serum were determined by ELISA - IgA, IgM, IgG, IgE, IL-1β, TNF-α, IL-4, IL-10 and AB to TPO. Results. It was found that these patients had a tendency to increase serum IgA, IgM, IgG and IgE compared to healthy individuals, but the intensity of changes was different. IL-1β and TNF-α were significantly higher in patients than in healthy individuals, by 5.12 and 6.03 times, respectively, and the tendency and intensity of their increase were similar. The amount of AB to TPO in patients was 21.41 times higher than in healthy individuals. Positive, direct, but varying strength correlations were found between serum immunoglobulins, cytokines and AB to TPO.
thyroid diseases, humoral immunity, immunoglobulins, cytokines, AB to TPO.заболевания щитовидной железы, гуморальный иммунитет, иммуноглобулины, цитокины, аутоантитела к ТПО.қалқонсимон без касалликлари, гуморал иммунитет, иммуноглобулинлар, цитокинлар, ТПО га қарши аутоантителолар.
Metadata source: the journal's OAI-PMH archive · Sindex does not store the full text; it links to the source.