Klinik fanlar yilnomasi Том 3 № 1 (2026)
MORPHOLOGICAL CHANGES IN THE PERIPHERAL LYMPH NODES OF 12-MONTH-OLD OUTBRED WHITE RATS WITH EXPERIMENTAL RHEUMATOID ARTHRITIS
Авезов Бахром Ботирович, Садиев Эрали Самиевич, Авезова Дилора Ботировна
Аннотация
The study examined morphological and morphometric changes in peripheral lymph nodes of 12-month-old outbred white rats with experimental rheumatoid arthritis. The total lymph node diameter, thickness of cortical and paracortical zones, number and size of lymphoid follicles, proportion of germinal centers, as well as medullary and stromal parameters were determined and statistically analyzed. The study demonstrates that experimental rheumatoid arthritis leads to pronounced structural alterations in lymph nodes, reflected by modifications in the relative distribution of lymphoid and stromal compartments.
experimental arthritis model, peripheral lymphoid tissue, quantitative morphometry, follicular lymphoid architecture, germinal center activity, stromal microenvironmentэкспериментальная модель артрита, периферическая лимфоидная ткань, количественная морфометрия, архитектура лимфоидных фолликулов, активность герминативных центров, стромальное микроокружениеtajribaviy artrit modeli, periferik limfoid to‘qima, miqdoriy morfometriya, limfoid follikulalar arxitekturasi, germinativ markaz faolligi, stromal mikro-muhit
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