Klinik fanlar yilnomasi Volume 3 Issue 1 (2026)

DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS

Ли Марина Станиславовна, Аликулова Хосият Икрамовна, Азимова Кудратой Исомовна

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Abstract

Objective. Systematization of data on drug-induced parkinsonism (DIP) to optimize diagnostic and treatment algorithms in neurological and psychiatric practice. Methods. An analytical review of modern clinical studies and guidelines for 2020–2025 regarding the epidemiology, pathogenesis, and therapy of DIP was conducted. Results. DIP ranks second among the causes of parkinsonism in the elderly. The main inducers are typical antipsychotics and calcium channel blockers (cinnarizine, flunarizine). Key criteria for differentiating DIP from Parkinson's disease (PD) were identified: symmetry of symptoms, subacute course, and lack of progression after drug withdrawal. The efficacy of amantadine as a first-line drug for DIP correction in elderly patients was confirmed due to a safety profile superior to anticholinergics. Conclusion. Timely identification of DIP and modification of pharmacotherapy (dose de-escalation, rotation of antipsychotics) allow for complete regression of symptoms in 75–85% of cases.

drug-induced parkinsonism, antipsychotics, extrapyramidal disorders, amantadine, differential diagnosisлекарственный паркинсонизм, антипсихотики, экстрапирамидные расстройства, амантадин, дифференциальная диагностикаdori vositalari keltirib chiqaradigan parkinsonizm, antipsixotiklar, ekstrapiramidal buzilishlar, amantadin, qiyosiy tashxis

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Cite

APA 7 
Ли Марина Станиславовна, Аликулова Хосият Икрамовна & Азимова Кудратой Исомовна (2026). DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS. Klinik fanlar yilnomasi, 3(1).
GOST R 7.0.5 
Ли Марина Станиславовна, Аликулова Хосият Икрамовна, Азимова Кудратой Исомовна DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS // Klinik fanlar yilnomasi. 2026. Т. 3. № 1.
BibTeX 
@article{станиславовна2026,
  author  = {Ли Марина Станиславовна and Аликулова Хосият Икрамовна and Азимова Кудратой Исомовна},
  title   = {DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS},
  journal = {Klinik fanlar yilnomasi},
  year    = {2026},
  volume  = {3},
  number  = {1}
}
RIS 
TY  - JOUR
AU  - Ли Марина Станиславовна
AU  - Аликулова Хосият Икрамовна
AU  - Азимова Кудратой Исомовна
TI  - DRUG-INDUCED PARKINSONISM: CLINICAL PREDICTORS, DIFFERENTIAL DIAGNOSIS, THERAPEUTIC ALGORITHMS
JO  - Klinik fanlar yilnomasi
PY  - 2026
VL  - 3
IS  - 1
ER  -