Klinik fanlar yilnomasi 3-том 2-нөмір (2026)
RELATIONSHIP BETWEEN CLINICAL STATUS, QUALITY OF LIFE AND PHYSICAL EXERCISE TOLERANCE INDICATORS WITH BIOMARKERS IN PATIENTS WITH CARDIORENAL SYNDROME
Гадаев А.Г, Халилова Ф.А, Гадаева Н.А, Бобоев А.Т
Аңдатпа
The article presents a comprehensive assessment of the relationship between clinical status (CSAS), quality of life (MLHFQ), and physical exercise tolerance (6-minute walk test — 6MWT) indicators with biomarkers in cardiorenal syndrome (CRS) developed against the background of chronic heart failure (CHF). The study included 240 participants: Group 1 — with CRS (n=100), Group 2 — CHF without CRS (n=100), Group 3 — control (n=40). In the CRS group, the CSAS score was 7.2±0.2 (control: 1.2±0.1, 6-fold higher), MLHFQ score — 56.4±1.7 (control: 8.5±0.8, 6.6-fold higher — low quality of life), 6MWT — 262±10 m (control: 525±14, 2-fold lower). G/G genotype carriers showed the most severe clinical course: CSAS — 7.9, MLHFQ — 61.6, 6MWT — 225.8 m (vs A/A; p<0.001). Correlations were established between 6MWT and uromodulin (r=+0.69), MLHFQ and uromodulin (r=−0.71), CSAS and NT-proBNP (r=+0.72). 4 diagrams and 2 tables are presented.
cardiorenal syndrome, clinical status assessment scale, quality of life, MLHFQ, 6-minute walk test, NYHA functional class, physical exercise, biomarkers, correlation analysis.кардиоренальный синдром, шкала оценки клинического состояния, качество жизни, MLHFQ, тест 6-минутной ходьбы, функциональный класс NYHA, физическая нагрузка, биомаркеры, корреляционный анализкардиоренал синдром, клиник ҳолат шкаласи, ҳаёт сифати, MLHFQ, 6-дақиқалик юриш синамаси, NYHA функционал синф, жисмоний юклама, биомаркерлар, корреляцион таҳлил
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