Klinik fanlar yilnomasi 3-tom 2-san (2026)
THE RELATIONSHIP BETWEEN GEOMETRIC TYPES OF LEFT VENTRICULAR REMODELING AND UROMODULIN LEVELS IN CARDIORENAL SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE
Гадаев А, Бобоев А.Т, Туракулов Р.И, Xaлилова Ф.А
Annotaciya
The article presents a comprehensive assessment of the relationship between geometric types of left ventricular remodeling and uromodulin levels in cardiorenal syndrome (CRS) associated with chronic heart failure (CHF). The study included 240 participants: Group 1 — with CRS (n=100), Group 2 — CHF without CRS (n=100), Group 3 — control (n=40). In the CRS group, LVMI was 142.5±3.2 g/m² (without CRS: 108.7±2.6; control: 84.3±2.1), relative wall thickness (RWT) — 0.48±0.01. LVH was identified in 90% of CRS patients: eccentric hypertrophy — 55%, concentric hypertrophy — 28%, concentric remodeling — 12%, normal geometry — 5%. Grade III diastolic dysfunction was found in 50% of CRS patients. Uromodulin levels strongly depended on remodeling type: normal geometry — 92.5±3.2 ng/ml, concentric remodeling — 75.3±2.5, concentric hypertrophy — 62.4±1.9, eccentric hypertrophy — 48.6±1.7 ng/ml (p<0.001). A strong inverse correlation was found between uromodulin and LVMI (r=−0.71, p<0.001). 4 figures and 2 tables are presented.
left ventricular remodeling, concentric hypertrophy, eccentric hypertrophy, relative wall thickness, uromodulin, cardiorenal syndrome, diastolic dysfunction, left ventricular mass index, echocardiography, correlation analysisремоделирование левого желудочка, концентрическая гипертрофия, эксцентрическая гипертрофия, относительная толщина стенки, уромодулин, кардиоренальный синдром, диастолическая дисфункция, индекс массы миокарда левого желудочка, эхокардиография, корреляционный анализчап қоринча ремоделинги, концентрик гипертрофия, эксцентрик гипертрофия, нисбий девор қалинлиги, уромодулин, кардиоренал синдром, диастолик дисфункция, чап қоринча миокарди индекси, эхокардиография, корреляцион таҳлил
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