Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) Том 1 № 3 (2020)
VITAMIN D DEFICIENCY IN HIGH-RISK PRE-ECLAMPSIA PATIENTS AND LABORATORY BLOOD CHANGES
Хамраев Хумоюн Хамзаевич
Аннотация
PE is responsible for almost 100 000 maternal deaths annually worldwide. Despite some advances in the study of PE, it is still a major cause of maternal mortality with no clear trend towards improvement [1, 2, 5]. Recent studies in different countries have drawn attention to the potential of vitamin D to reduce the risk of PE. It is believed that the active form of vitamin D-1,25 (OH) 2D regulates the transcription and function of genes related to trophoblast invasion, normal implantation and angiogenesis. Vitamin D (1α,25-dihydroxyvitamin D3) exerts its effects on cells through both genetically mediated and non-genetic pathways. They include both long-term modulation of gene expression (genetic mechanism) and short-term activation of intracellular communication (non-genetic mechanism).
Преэклампсия, дефицит витамина D, беременность, репродуктивные и перинатальные потериPreeclampsia, vitamin D deficiency, pregnancy, reproductive and perinatal lossesPreeklampsiya, D vitamini etishmovchiligi, homiladorlik, reproduktiv va perinatal yo'qotishlar
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