Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) 4-tom 3-san (2023)
CLINICAL AND PHYSIOLOGICAL CHARACTERISTICS OF SPINAL ANESTHESIA WITH QUANADEX DURING CESAREAN SECTION
Куличкин Юрий Всеволодович, Ким Ен – Дин, Ильхамов Акмаль Фаикович, Камилов Азиз Исраилович, Джураев Фарход Салахиддинович, Хайдаров Фахритдин Шухратович
Annotaciya
The purpose of this research was to study Quanadex as an adjuvant to Longocain Heavy 0.5% solution for injections for clinical and physiological characteristics, efficacy and neonatal outcomes during cesarean section. A prospective double-blind randomized controlled clinical trial was conducted in 189 women, without severe extragenital pathology, with ASA II physical status. Group I consisted of pregnant women who were intrathecally injected with Longocain Heavy 0.5% hyperbaric solution, Group II women were injected with Longocain Heavy 0.5% hyperbaric solution in combination with 6 mcg Quanadex. The intravenous infusion of balanced polyelectrolyte hyperosmolar solution of Reosorbilact in a volume of 3–5 ml/kg preceded the spinal injection. Central hemodynamics, ANS, interleukin-6 were assessed, and newborns were evaluated on the Apgar scale at the 1st and 5th minutes. Studies have shown that the use of Quanadex, a highly selective α2-adrenergic receptor agonist, as an adjuvant to a 0.5% solution of Longocaine Heavy accelerates the onset of sensory-motor blockade, provides a longer sensory-motor block without significant effect on hemodynamics and ANS parameters, significantly reduces anesthetic and surgical stress and does not have a depressive effect on newborns in neonatal period of adaptation.
Спинальная анестезия, кесарево сечение, кванадекс, α2 – адренорецептор, лонгокаин хеви, сенсорно – моторный блокQuanadex, Longocaine Heavy, spinal anesthesia, Reosorbilact, interleukin-6, central hemodynamics, α2-adrenoreceptorKvanadeks, Longokain Xevi, spinal anesteziya, Reosorbilakt, interleykin-6, markaziy gemodinamika, α2-adrenoretseptor
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