Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) Том 5 № 3 (2024)
DISORDER OF GROWTH FACTOR REGULATION AND PLACENTAL DYSFUNCTION
Жураева Дильдора Мухиддиновна, Мусаходжаева Дилорам Абдуллаевна, Азизова Зухра Шухратовна, Ешимбетова Гульсара Закировна
Аннотация
Objective: to study serum growth factors in women with placental dysfunction (PD). Material and methods. The study involved 47 pregnant women, with a gestation period of 26-40 weeks, with an established diagnosis of placental dysfunction, who were under observation in the obstetric department of the City Maternity Complex No. 3 in Tashkent. Determination of serum levels of growth factors was carried out by ELISA, in accordance with the manufacturer's recommendations. Results. It was found that pregnant women with PD at 26-40 weeks of gestation have significant dysregulation of growth factors and vascular activity, which is manifested in a significant decrease in the levels of VEGF-A and PlGF in the peripheral blood serum, as well as a significant increase in the level of sFlt-1. These changes lead to a pronounced imbalance in the ratio of sFlt-1 to PlGF, which can contribute to deterioration of placental function and is associated with the development of pathological conditions.
беременность, плацентарная дисфункция, цитокины, факторы роста сосудов, ангиогенез, сыворотка, дисбалансpregnancy, placental dysfunction, cytokines, vascular growth factors, angiogenesis, serum, imbalancehomiladorlik, platsenta disfunktsiyasi, sitokinlar, qon tomirlarining o‘sish omillari, angiogenez, qon zardobi, disbalans
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