Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) Том 7 № 1 (2026)
CHARACTERISTICS OF THE FORMATION OF THE REPRODUCTIVE SYSTEM IN GIRLS WITH CONGENITAL DYSFUNCTION OF THE ADRENAL CORTEX
Шопўлатов Эркин Холтожиевич, Эгамқулов Зайниддин Тошмухаммедович, Ганиев Фахриддин Истамқулович, Наил Салаватович Фатхулин, Шавкатов Ҳасан Шавкатович, Самадова Машхура Ёқубжон қизи
Аннотация
The aim of this study was to analyze the characteristics of the formation and functioning of the reproductive system in girls with congenital adrenal cortex dysfunction based on clinical, hormonal, and instrumental examination methods. The study was conducted between 2020 and 2026 in medical institutions of the Samarkand region and included a retrospective and prospective analysis of 20 patients under dynamic observation. The assessment comprised age and socio-demographic characteristics, general somatic status, anthropometric parameters, gynecological status, features of menstrual function, as well as the results of laboratory investigations (17-hydroxyprogesterone, testosterone, DHEA-S, cortisol) and ultrasound examination of the reproductive organs. The results demonstrated that the majority of girls with congenital adrenal cortex dysfunction exhibited clinical signs of hyperandrogenism, including acne, seborrhea, male-pattern hair growth, clitoromegaly, and insufficient development of the mammary glands. Menstrual cycle disorders were common, with opsomenorrhea and oligomenorrhea predominating, while amenorrhea and algodysmenorrhea were observed less frequently. Ultrasound findings revealed reduced uterine and ovarian sizes compared with age norms, and in some cases, polycystic ovarian changes. These findings confirm the significant negative impact of congenital adrenal cortex dysfunction on reproductive system development and emphasize the importance of early diagnosis and a comprehensive multidisciplinary approach to the management of affected patients
врождённая дисфункция коры надпочечников, гиперандрогения, девочки, репродуктивная система, менструальный цикл, недостаточность 21-гидроксилазы.congenital adrenal cortex dysfunction, hyperandrogenism, girls, reproductive system, menstrual cycle, 21-hydroxylase deficiency.: buyrak usti bezi po‘stlog‘ining tug‘ma disfunktsiyasi, giperandrogeniya, qizlar, reproduktiv tizim, hayz sikli, 21-gidroksilaza yetishmovchiligi
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