Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) 6-jild 4-son (2025)
PRECACHEXIA BIOMARKERS IN WOMEN WITH REPRODUCTIVE SYSTEM CANCER: A COMPREHENSIVE DIAGNOSTIC APPROACH
Мамедов Умид Суннатович, Гайсина Елена Александровна, Рахимов Нодир Махамматкулович
Annotatsiya
Objective: To develop and validate a diagnostic panel of biomarkers for early detection of precachexia in cancer patients. Materials and Methods: A prospective cohort study was conducted involving 197 patients, divided into three groups based on nutritional status: normal (n=64), precachexia (n=81), and cachexia (n=52). ROC analysis, internal consistency assessment (Cronbach's α), test-retest analysis, and correlation study methods were used. Biomarkers included C-reactive protein, interleukin-6, tumor necrosis factor-α, and albumin. Results: A statistically significant increase in inflammatory markers was found with the progression of nutritional deficiency. Interleukin-6 demonstrated the highest diagnostic value (area under the ROC curve 0.899). A combined model was developed with 91.1% sensitivity and 92.4% specificity, superior to individual biomarkers. Conclusions: A comprehensive approach to assessing inflammation and protein metabolism biomarkers significantly improves the accuracy of early precachexia diagnosis in cancer patients. The proposed diagnostic model can be recommended for clinical use to timely identify nutritional disorders.
прекахексия, онкология, биомаркеры, интерлейкин-6, нутритивный статусprecachexia, oncology, biomarkers, interleukin-6, nutritional statusprekaxeksiya, onkologiya, biomarkerlar, interleykin-6, oziq-ovqat statusi
Metadata manbasi: jurnal OAI-PMH arxivi · Sindex toʻliq matnni saqlamaydi, manbaga havola beradi.