Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali Volume 3 Issue 3 (2022)
PRECLINICAL DRUG DEVELOPMENT PROCESS OF RHEUMATOID ARTHRITIS MECHANISMS TO STUDY MORPHOLOGICAL CHANGES IN THE CELL AND VASCULAR STRUCTURE OF THE HEART IN EXPERIMENTAL ANIMALS
Саидова Мухаббат Мухиддиновна
Abstract
Purpose of the study: to study the preclinical process of drug development of rheumatoid arthritis mechanisms to study morphological changes in the structure of cells and vessels of the heart in experimental animals Materials and Methods. Complete Freund's adjuvant for rheumatoid arthritis was applied to 100 white randomized rats aged between 18 and 24 months in the inpatient vivarium of the Bukhara State Medical Institute. Results and discussion: While investigating the preclinical drug development process of rheumatoid arthritis mechanisms to study morphological changes in the cell structure and vascular structure of the heart in experimental animals, it is important to note that animals do not naturally develop autoimmune diseases such as RA, which is an inherent limitation of these arthritis models. The results have shown that modern therapeutic approaches using modern biological agents are very successful and effective in most patients with RA, including those with severe disease progression. Conclusions: The presence of the influence of simulated rheumatoid arthritis on the heart was determined which testifies to the fact that this pathology has a sufficient level of risk for the organism.
ревматоидный артрит, сердечно-сосудистый риск, профилактикаrheumatoid arthritis, cardiovascular risk, preventionRevmatoid artrit, yurak-qon tomir xavfi, oldini olish
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