Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali 4-том 1-сан (2023)
THE VALUE OF NEUTROPHIL ELASTASE IN THE DEVELOPMENT OF NONSPECIFIC INTERSTITIAL PNEUMONIA
Махматмурадова Наргиза Негматуллаевна
Аннотация
The aim of the study was to establish the significance of neutrophil elastase in the development of nonspecific interstitial pneumonia.Material and methods of research. As a material, we examined 140 patients with nonspecific interstitial pneumonia who were on inpatient treatment in the pulmonology department of the Samarkand City Medical Association. A total of 140 patients with an established diagnosis of NIP of various localization were examined. The results obtained indicate the absence of statistically significant intergroup differences (by sputum phenotypes) in the values of the studied parameters (neutrophil elastase) in patients with NIP. It was found that in patients with cough with sputum, the level of neutrophil elastase was significantly higher than in patients without sputum, which confirms the participation of enzymes in the formation of inflammation in patients of the studied groups. Thus, the data obtained indicate an increase in the content of neutrophil elastase in patients with nonspecific interstitial pneumonia. At the same time, the highest rates of neutrophil elastase were observed in the groups with severe and moderate severity, less in the group with mild course, but more than twice as much as in the control groups of the examined individuals. Although there were no significant differences in the analyzed trait in patients with a more severe course.
неспецифическая интерстициальная пневмония, сыворотка крови, нейтрофильная эластазаnonspecific interstitial pneumonia, blood serum, neutrophil elastasenonspesifik interstitsial pnevmoniya, qon zardobi, neytrofil elastaza
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