Journal of cardiorespiratory research/Kardiorespirator tadqiqotlar jurnali Volume 4 Issue 3 (2023)
BENEFICIAL IMPACT OF WEIGHT LOSS ON RESPIRATORY FUNCTION IN INTERSTITIAL LUNG DISEASE PATIENTS WITH OBESITY
Закиряева Парвина Одиловна, Ахатова Вазира Пардакуловна
Abstract
Objective: study aimed to clarify the effect of weight loss on pulmonary function test (PFT) in ILD patients with obesity. Methods: In a case-control study, 76 patients with bladder cancer with IL-1B-511 biallelic polymorphism were included, the number of tandem repeats was genotyped. Results: Among all consecutive ILD patients with a body mass index (BMI)27 kg/m2 who received nutrition education for improving obesity between June 2018 and December 18, we retrospectively included patients who successfully decreased their body weight by over2 kg and underwent follow-up PFT within 6 months. The results of PFT at baseline and follow-up and the level of Krebs von den Lungen-6 (KL-6) were compared.A significant association was found between IL-1 polymorphism and an increased risk of recurrence in patients with urothelial bladder cancer. There was no significant relationship in patients with G1. Carriers homozygous for IL-1B-511T / C had an increased risk of recurrent bladder cancer with odds ratios 2.7 (95% confidence interval [CI], 1.5-4.9) and 3.1 (95% CI, 1.5. –6.5) respectively. Statistical analysis showed an interaction between the two loci with risk associated with IL-1B. The -511T allele increased significantly (odds ratio, 9.0; 95% CI, 3.5-23.0). Conclusions. In ILD patients with obesity, weight loss is important and potentially improves their disease course.
интерстициальным заболеванием легких, избыточным весом, тест функции легких, индексом массы тела, монооксид углеродаinterstitial lung disease, overweight, pulmonary function test, body mass index, carbon monoxideo’pka interstitial kasalligi, ortiqcha vazn, nafas olish funksiya testi, tana massasi indeksi, monooksid uglerod
Metadata source: the journal's OAI-PMH archive · Sindex does not store the full text; it links to the source.