Марказий Осиё эндокринологик журнали Ҷилди 3 № 2 (2023)
PRECOCIOUS PUBERTY: MOLECULAR GENETICS, MODERN APPROACHES TO THE DIAGNOSIS AND TREATMENT
Халимова З.Ю., Уралова Д.У., Абдуллаева А.У., Холова Д.Ш., Рахимова Г.Н., Сулейманова Ф.Н.
Аннотатсия
The article is devoted to the basic molecular-genetic mechanisms and novel approaches to the diagnosis and management of the development of central precocious puberty. Precocious puberty is the appearance of the secondary sexual characteristics before the age years in girls and before 9 years in boys. Prevalence varies greatly by study. The incidence is generally thought to be 1 in 5000-10000 children, but some countries around the world have seen an increase in the incidence, including the United States, Spain, France, Denmark, Korea and China since 1990. Complex interactions with genetic, nutritional and environmental factors play a decisive role in determining the timing of puberty. To date, mutations in four genes (KISS1, KISS1R, MKRN3, DLK1) have been confirmed as causal variants leading to central idiopathic Precocious Puberty.
преждевременное половое созревание, центральное преждевременное половое развитие (ЦППР), периферическое преждевременное половое развитие (ПППР), идиопатическое, KISS1, KISS1R, MKRN3, DLK1, врожденная дисфункция коры надпочечников, синдром Мак-Кьюна-Олбрайтаprecocious puberty (PP), central precocious puberty (CPP), peripheral precocious puberty (PPP), idiopathic, KISS1, KISS1R, MKRN3, DLK1, congenital adrenal hyperplasia, Mc- Cune Albright syndromeerta jinsiy yetilish (EJY), markaziy erta jinsiy yetilish (MEJY), periferik erta jinsiy yetilish (PEJY),idiopatik, KISS1, KISS1R, MKRN3, DLK1, buyrakusti bezi po’stlog’i
Манбаи метамаълумот: бойгонии OAI-PMH-и маҷалла · Sindex матни пурраро нигоҳ намедорад, ба манбаъ пайванд медиҳад.