O‘zbekiston кardiologiyasi Ҷилди 1 № 2 (2024) · Саҳифаҳои 122-131

Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs

Файзуллаева, Ш, Хамидуллаева, Г, Абдуллаева, Г, Юсупова, Х, Бекметова, С, Юлдашева, А, Fayzullayeva, Shakhlo, Khamidullayeva, Gulnoza, Abdullayeva, Guzal, Yusupova, Hafiza, Bekmetova, Sevara, Yuldasheva, Alina, Fayzullayeva, Shaxlo, Xamidullayeva, Gulnoza, Abdullayeva, Guzal, Yusupova, Hafiza, Bekmetova, Sevara, Yuldasheva, Alina

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Аннотатсия

Background. Uncontrolled arterial hypertension in patients at high and very high cardiovascular risk remains a significant issue in modern medicine. Optimizing antihypertensive therapy using fixed or separate combinations of drugs represents a promising approach to improving blood pressure control and reducing the risk of cardiovascular complications. Materials and methods. The study included 40 patients (men and women) with grade I–III hypertension according to the ESC/ESH classification (2018). The mean age was 51.52 ± 9.43 years, and the average disease duration was 8.52 ± 6.64 years. Patients were divided into two groups: one received a fixed combination (lisinopril/amlodipine/rosuvastatin), and the other received a separate combination (perindopril/amlodipine and rosuvastatin). Treatment lasted for 3 months. Effectiveness was assessed using 24-hour blood pressure monitoring, applanation tonometry, echocardiography, ultrasound examination of brachiocephalic arteries, and laboratory analyses (lipid profile, glucose level, uric acid, and creatinine). Results. Both therapy regimens demonstrated high antihypertensive, organoprotective, and hypolipidemic effectiveness. However, patients receiving the fixed combination showed a more significant reduction in systolic and diastolic blood pressure, improved lipid profile, and decreased nighttime blood pressure variability. No adverse effects on metabolic profiles were observed. Conclusion. The fixed combination of drugs demonstrated superiority over the separate combination regimen, providing better blood pressure control and lipid profile improvement. These findings highlight the importance of selecting optimal therapy regimens for high cardiovascular risk patients and confirm the efficacy of fixed combinations in this patient group.

arterial hypertensionblood Pressure ControlACE inhibitorscalcium channel blockersstatinscardiovascular risk managementaртериальная гипертензияконтроль артериального давленияингибиторы АПФблокаторы кальциевых каналов

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Иқтибос гирифтан

APA 7 
Файзуллаева, Ш, Хамидуллаева, Г, Абдуллаева, Г, Юсупова, Х, Бекметова, С, Юлдашева, А, Fayzullayeva, Shakhlo, Khamidullayeva, Gulnoza, Abdullayeva, Guzal, Yusupova, Hafiza, Bekmetova, Sevara, Yuldasheva, Alina, Fayzullayeva, Shaxlo, Xamidullayeva, Gulnoza, Abdullayeva, Guzal, Yusupova, Hafiza, Bekmetova, Sevara & Yuldasheva, Alina (2024). Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs. O‘zbekiston кardiologiyasi, 1(2), 122-131.
GOST R 7.0.5 
Файзуллаева, Ш, Хамидуллаева, Г, Абдуллаева, Г, Юсупова, Х, Бекметова, С, Юлдашева, А, Fayzullayeva, Shakhlo, Khamidullayeva, Gulnoza, Abdullayeva, Guzal, Yusupova, Hafiza, Bekmetova, Sevara, Yuldasheva, Alina, Fayzullayeva, Shaxlo, Xamidullayeva, Gulnoza, Abdullayeva, Guzal, Yusupova, Hafiza, Bekmetova, Sevara, Yuldasheva, Alina Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs // O‘zbekiston кardiologiyasi. 2024. Т. 1. № 2. С. 122-131.
BibTeX 
@article{ш2024,
  author  = {Файзуллаева, Ш and Хамидуллаева, Г and Абдуллаева, Г and Юсупова, Х and Бекметова, С and Юлдашева, А and Fayzullayeva, Shakhlo and Khamidullayeva, Gulnoza and Abdullayeva, Guzal and Yusupova, Hafiza and Bekmetova, Sevara and Yuldasheva, Alina and Fayzullayeva, Shaxlo and Xamidullayeva, Gulnoza and Abdullayeva, Guzal and Yusupova, Hafiza and Bekmetova, Sevara and Yuldasheva, Alina},
  title   = {Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs},
  journal = {O‘zbekiston кardiologiyasi},
  year    = {2024},
  volume  = {1},
  number  = {2},
  pages   = {122-131}
}
RIS 
TY  - JOUR
AU  - Файзуллаева, Ш
AU  - Хамидуллаева, Г
AU  - Абдуллаева, Г
AU  - Юсупова, Х
AU  - Бекметова, С
AU  - Юлдашева, А
AU  - Fayzullayeva, Shakhlo
AU  - Khamidullayeva, Gulnoza
AU  - Abdullayeva, Guzal
AU  - Yusupova, Hafiza
AU  - Bekmetova, Sevara
AU  - Yuldasheva, Alina
AU  - Fayzullayeva, Shaxlo
AU  - Xamidullayeva, Gulnoza
AU  - Abdullayeva, Guzal
AU  - Yusupova, Hafiza
AU  - Bekmetova, Sevara
AU  - Yuldasheva, Alina
TI  - Individualized approach to high-risk therapy: comparative assessment of fixed and separate combinations of antihypertensive and hypolipidemic drugs
JO  - O‘zbekiston кardiologiyasi
PY  - 2024
VL  - 1
IS  - 2
SP  - 122
EP  - 131
ER  -