O‘zbekiston кardiologiyasi Volume 1 Issue 2 (2024) · pp. 112-121

Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation

Хамидуллаева, Г, Абдуллаева, Г, Тургунбоев, С, Сафаров, Ж, Ибрагимова, И, Раджабова, Guliruh, Khamidullaeva, Gulnoz, Abdullaeva, Guzal, Turgunboev, Saidburkhan, Safarov, Jamshiddin, Ibragimova, Iroda, Radzhabova, Guliruh, Хamidullaeva, Gulnoz, Abdullaeva, Guzal, Turgunboev, Saidburkhan, Safarov, Jamshiddin, Ibragimova, Iroda, Radzhabova, Guliruh

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Abstract

Background. The purpose of this study was to compare the tolerability, safety, and clinical efficacy of generic and original apixaban in patients with arterial hypertension (AH) and permanent non-valvular atrial fibrillation (AF). Materials and methods. This prospective study included 50 patients with hypertension stages 1-3 and permanent non-valvular atrial fibrillation. The patients were divided into two groups: Group 1 (n=25) received generic apixaban, and Group 2 (n=25) received the original apixaban. Both groups were administered 10 mg of apixaban daily, in combination with standard antihypertensive therapy. Clinical and laboratory evaluations were performed before and after one month of treatment, including measurements of blood pressure, echocardiography, biochemical blood tests, and coagulogram. Results. A significant reduction in systolic and diastolic blood pressure was observed in both groups. No significant changes were detected in echocardiographic parameters. Biochemical tests revealed a decrease in creatinine and uric acid levels, and an increase in the prothrombin ratio, indicating a positive anticoagulant effect. Conclusion. Both generic and original apixaban showed similar safety and clinical efficacy in patients with arterial hypertension and permanent atrial fibrillation, demonstrating significant reductions in blood pressure and positive anticoagulant effects.

arterial hypertensionatrial fibrillationgeneric apixabanoriginal apixabananticoagulant therapyaртериальная гипертензияфибрилляция предсердийгенерический апиксабаноригинальный апиксабанантикоагулянтная терапия

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APA 7 
Хамидуллаева, Г, Абдуллаева, Г, Тургунбоев, С, Сафаров, Ж, Ибрагимова, И, Раджабова, Guliruh, Khamidullaeva, Gulnoz, Abdullaeva, Guzal, Turgunboev, Saidburkhan, Safarov, Jamshiddin, Ibragimova, Iroda, Radzhabova, Guliruh, Хamidullaeva, Gulnoz, Abdullaeva, Guzal, Turgunboev, Saidburkhan, Safarov, Jamshiddin, Ibragimova, Iroda & Radzhabova, Guliruh (2024). Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation. O‘zbekiston кardiologiyasi, 1(2), 112-121.
GOST R 7.0.5 
Хамидуллаева, Г, Абдуллаева, Г, Тургунбоев, С, Сафаров, Ж, Ибрагимова, И, Раджабова, Guliruh, Khamidullaeva, Gulnoz, Abdullaeva, Guzal, Turgunboev, Saidburkhan, Safarov, Jamshiddin, Ibragimova, Iroda, Radzhabova, Guliruh, Хamidullaeva, Gulnoz, Abdullaeva, Guzal, Turgunboev, Saidburkhan, Safarov, Jamshiddin, Ibragimova, Iroda, Radzhabova, Guliruh Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation // O‘zbekiston кardiologiyasi. 2024. Т. 1. № 2. С. 112-121.
BibTeX 
@article{г2024,
  author  = {Хамидуллаева, Г and Абдуллаева, Г and Тургунбоев, С and Сафаров, Ж and Ибрагимова, И and Раджабова, Guliruh and Khamidullaeva, Gulnoz and Abdullaeva, Guzal and Turgunboev, Saidburkhan and Safarov, Jamshiddin and Ibragimova, Iroda and Radzhabova, Guliruh and Хamidullaeva, Gulnoz and Abdullaeva, Guzal and Turgunboev, Saidburkhan and Safarov, Jamshiddin and Ibragimova, Iroda and Radzhabova, Guliruh},
  title   = {Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation},
  journal = {O‘zbekiston кardiologiyasi},
  year    = {2024},
  volume  = {1},
  number  = {2},
  pages   = {112-121}
}
RIS 
TY  - JOUR
AU  - Хамидуллаева, Г
AU  - Абдуллаева, Г
AU  - Тургунбоев, С
AU  - Сафаров, Ж
AU  - Ибрагимова, И
AU  - Раджабова, Guliruh
AU  - Khamidullaeva, Gulnoz
AU  - Abdullaeva, Guzal
AU  - Turgunboev, Saidburkhan
AU  - Safarov, Jamshiddin
AU  - Ibragimova, Iroda
AU  - Radzhabova, Guliruh
AU  - Хamidullaeva, Gulnoz
AU  - Abdullaeva, Guzal
AU  - Turgunboev, Saidburkhan
AU  - Safarov, Jamshiddin
AU  - Ibragimova, Iroda
AU  - Radzhabova, Guliruh
TI  - Comparative clinical effectiveness of generic and original apixaban in anticoagulant therapy for patients with arterial hypertension and permanent atrial fibrillation
JO  - O‘zbekiston кardiologiyasi
PY  - 2024
VL  - 1
IS  - 2
SP  - 112
EP  - 121
ER  -