O‘zbekiston кardiologiyasi 2-том 3-сан (2025) · 248-263-беттер

The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index

Юсупалиева, Д, Алиева, Р, Ахмедова, Ш, Шек, А, Yusupaliyeva, Dilnora, Aliyeva, Rano, Axmedova, Shoxista, Shek, Aleksandr, Yusupaliyeva, Dilnora, Aliyeva, Rano, Akhmedova, Shokhista, Shek, Aleksandr

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Аннотация

In recent years, researchers have focused on the role of various adipose tissue depots in the development of coronary artery disease (CAD), extending beyond traditional obesity assessments based on body mass index (BMI). Visceral adipose tissue, epicardial fat, fatty liver disease (currently termed metabolic dysfunction-associated steatotic liver disease), and perivascular adipose tissue actively participate in CAD pathogenesis through mechanisms of systemic inflammation, oxidative stress, endothelial dysfunction, and atherosclerosis. Visceral fat, characterized by high metabolic activity, secretes proinflammatory cytokines that promote insulin resistance and atherosclerosis. Epicardial fat surrounding the coronary arteries exerts local effects by releasing adipokines that may accelerate the progression of atherosclerotic plaques. Fatty liver disease is associated with dyslipidemia and enhanced systemic inflammation, increasing cardiovascular risk. Perivascular adipose tissue regulates vascular tone and inflammation, and its dysfunction contributes to arterial stiffness and hypertension. The relevance of studying these adipose depots lies in the need to identify new biomarkers and targets for personalized prevention and treatment of CAD. Traditional obesity assessment methods such as BMI, fail to reflect adipose tissue distribution and metabolic activity, underscoring the importance of more detailed investigation into the role of various fat depots in cardiovascular pathology.

ишемическая болезнь сердцалокальные жировые депоожирениевисцеральное ожирениеэпикардиальная жировая тканьассоциированная с метаболической дисфункцией стеатозная болезнь печенипериваскулярная жировая тканьcoronary artery diseaselocal adipose depotsobesity

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Цитата алуу

APA 7 
Юсупалиева, Д, Алиева, Р, Ахмедова, Ш, Шек, А, Yusupaliyeva, Dilnora, Aliyeva, Rano, Axmedova, Shoxista, Shek, Aleksandr, Yusupaliyeva, Dilnora, Aliyeva, Rano, Akhmedova, Shokhista & Shek, Aleksandr (2025). The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index. O‘zbekiston кardiologiyasi, 2(3), 248-263.
GOST R 7.0.5 
Юсупалиева, Д, Алиева, Р, Ахмедова, Ш, Шек, А, Yusupaliyeva, Dilnora, Aliyeva, Rano, Axmedova, Shoxista, Shek, Aleksandr, Yusupaliyeva, Dilnora, Aliyeva, Rano, Akhmedova, Shokhista, Shek, Aleksandr The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index // O‘zbekiston кardiologiyasi. 2025. Т. 2. № 3. С. 248-263.
BibTeX 
@article{д2025,
  author  = {Юсупалиева, Д and Алиева, Р and Ахмедова, Ш and Шек, А and Yusupaliyeva, Dilnora and Aliyeva, Rano and Axmedova, Shoxista and Shek, Aleksandr and Yusupaliyeva, Dilnora and Aliyeva, Rano and Akhmedova, Shokhista and Shek, Aleksandr},
  title   = {The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index},
  journal = {O‘zbekiston кardiologiyasi},
  year    = {2025},
  volume  = {2},
  number  = {3},
  pages   = {248-263}
}
RIS 
TY  - JOUR
AU  - Юсупалиева, Д
AU  - Алиева, Р
AU  - Ахмедова, Ш
AU  - Шек, А
AU  - Yusupaliyeva, Dilnora
AU  - Aliyeva, Rano
AU  - Axmedova, Shoxista
AU  - Shek, Aleksandr
AU  - Yusupaliyeva, Dilnora
AU  - Aliyeva, Rano
AU  - Akhmedova, Shokhista
AU  - Shek, Aleksandr
TI  - The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index
JO  - O‘zbekiston кardiologiyasi
PY  - 2025
VL  - 2
IS  - 3
SP  - 248
EP  - 263
ER  -