O‘zbekiston кardiologiyasi 2-jild 4-son (2025) · 348-354-betlar

Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy

Абдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev, Timur, Raxmatov, Mahmud, Gulomov, Xumoyun, Abdullayev, Timur, Rakhmatov, Mahmud, Gulomov, Khumoyun

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Annotatsiya

Aim. The aim of this study was to investigate the relationship between clinical-hemodynamic parameters and inflammatory markers (C-reactive protein, interleukin-6, tumor necrosis factor-α) in patients with dilated cardiomyopathy. Materials and methods. The study included 42 patients (mean age 38.5±1.2 years) with dilated cardiomyopathy and chronic heart failure classified as NYHA functional class II–IV. The patients were divided into two groups: Group I – class II (n=12) and Group II – class III–IV (n=30). Results. As heart failure severity increased (class III–IV), serum levels of C-reactive protein (7.6±1.1 mg/L vs. 4.1±0.6 mg/L, p<0.05), IL-6 (7.5±0.8 pg/mL vs. 4.6±0.2 pg/mL, p<0.01), and TNF- α (8.1±0.9 pg/mL vs. 5.6±0.7 pg/mL, p<0.05) were significantly elevated. These changes were associated with left ventricular dilatation (LVEDD 58±1 mm, p<0.05) and reduced ejection fraction (34.7±1.8%, p<0.05). Conclusion. The findings suggest that inflammatory markers play a crucial role in assessing the severity and prognosis of dilated cardiomyopathy and chronic heart failure.

dilated cardiomyopathychronic heart failureinflammationC-reactive proteininterleukin-6tumor necrosis factor-αcolchicineдилатационная кардиомиопатияхроническая сердечная недостаточностьвоспаление

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Iqtibos olish

APA 7 
Абдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev, Timur, Raxmatov, Mahmud, Gulomov, Xumoyun, Abdullayev, Timur, Rakhmatov, Mahmud & Gulomov, Khumoyun (2025). Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy. O‘zbekiston кardiologiyasi, 2(4), 348-354.
GOST R 7.0.5 
Абдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev, Timur, Raxmatov, Mahmud, Gulomov, Xumoyun, Abdullayev, Timur, Rakhmatov, Mahmud, Gulomov, Khumoyun Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy // O‘zbekiston кardiologiyasi. 2025. Т. 2. № 4. С. 348-354.
BibTeX 
@article{т2025,
  author  = {Абдуллаев, Т and Рахматов, М and Гуломов, Х and Abdullayev, Timur and Raxmatov, Mahmud and Gulomov, Xumoyun and Abdullayev, Timur and Rakhmatov, Mahmud and Gulomov, Khumoyun},
  title   = {Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy},
  journal = {O‘zbekiston кardiologiyasi},
  year    = {2025},
  volume  = {2},
  number  = {4},
  pages   = {348-354}
}
RIS 
TY  - JOUR
AU  - Абдуллаев, Т
AU  - Рахматов, М
AU  - Гуломов, Х
AU  - Abdullayev, Timur
AU  - Raxmatov, Mahmud
AU  - Gulomov, Xumoyun
AU  - Abdullayev, Timur
AU  - Rakhmatov, Mahmud
AU  - Gulomov, Khumoyun
TI  - Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy
JO  - O‘zbekiston кardiologiyasi
PY  - 2025
VL  - 2
IS  - 4
SP  - 348
EP  - 354
ER  -