O‘zbekiston кardiologiyasi Том 2 № 4 (2025) · с. 348-354
Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy
Абдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev, Timur, Raxmatov, Mahmud, Gulomov, Xumoyun, Abdullayev, Timur, Rakhmatov, Mahmud, Gulomov, Khumoyun
Аннотация
Aim. The aim of this study was to investigate the relationship between clinical-hemodynamic parameters and inflammatory markers (C-reactive protein, interleukin-6, tumor necrosis factor-α) in patients with dilated cardiomyopathy. Materials and methods. The study included 42 patients (mean age 38.5±1.2 years) with dilated cardiomyopathy and chronic heart failure classified as NYHA functional class II–IV. The patients were divided into two groups: Group I – class II (n=12) and Group II – class III–IV (n=30). Results. As heart failure severity increased (class III–IV), serum levels of C-reactive protein (7.6±1.1 mg/L vs. 4.1±0.6 mg/L, p<0.05), IL-6 (7.5±0.8 pg/mL vs. 4.6±0.2 pg/mL, p<0.01), and TNF- α (8.1±0.9 pg/mL vs. 5.6±0.7 pg/mL, p<0.05) were significantly elevated. These changes were associated with left ventricular dilatation (LVEDD 58±1 mm, p<0.05) and reduced ejection fraction (34.7±1.8%, p<0.05). Conclusion. The findings suggest that inflammatory markers play a crucial role in assessing the severity and prognosis of dilated cardiomyopathy and chronic heart failure.
dilated cardiomyopathychronic heart failureinflammationC-reactive proteininterleukin-6tumor necrosis factor-αcolchicineдилатационная кардиомиопатияхроническая сердечная недостаточностьвоспаление
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