O‘zbekiston кardiologiyasi 3-том 1-сан (2026) · 16-25-беттер
Clinical efficacy of combined treatment methods in uncontrolled arterial hypertension during pregnancy
Sadulloyeva, M, Zakirova, F, Садуллоева, Мохинур, Закирова, Феруза, Sadulloyeva, M, Zakirova, F
Аннотация
Aim: To evaluate the effect of combined antihypertensive therapy on arterial blood pressure parameters in pregnant women with uncontrolled gestational arterial hypertension. Materials and methods: The study included 60 pregnant women diagnosed with gestational arterial hypertension according to the 2018 ESC recommendations, with a gestational age of 20–24 weeks. The patients were randomly divided into two groups: Group 1 (n = 30) — methyldopa (500–1000 mg) + metoprolol succinate (25–50 mg), Group 2 (n = 30) — methyldopa (500–1000 mg) + amlodipine (5–10 mg). In all patients, office arterial blood pressure was measured and 24-hour ambulatory blood pressure monitoring was performed before the initiation of antihypertensive therapy. Results: A significant decrease in systolic, diastolic, and mean arterial blood pressure was recorded in both groups (p < 0.0001). The degree of blood pressure reduction was higher in Group 2 in terms of systolic and diastolic parameters, which may be explained by the vasodilatory effect of amlodipine. Target systolic blood pressure was observed in 75% of patients in Group 1 and 87% of patients in Group 2, while target diastolic blood pressure was observed in 75% and 91% of patients, respectively. However, no statistically significant difference was found between the groups. Conclusion: Both combined antihypertensive therapy regimens ensured the achievement of target arterial blood pressure levels in pregnant women with gestational arterial hypertension. Although the methyldopa and amlodipine combination showed a greater tendency toward blood pressure reduction, larger studies are required to confirm these results.
Gestational arterial hypertensionpregnancyantihypertensive therapyABP target valuesГестационная артериальная гипертензиябеременностьантигипертензивная терапияцелевые показатели АДGestatsion arterial gipertenziyahomiladorlik
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