O‘zbekiston кardiologiyasi 3-том 2-сан (2026) · 55-62-беттер

The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting

Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali, Умеров, С, Курбанов, Нурали, Ганиев, О, Юсупов, Ж, Курбанов, Н, Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali

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Аннотация

The progression of chronic heart failure (CHF) after coronary artery bypass grafting (CABG) remains a pressing issue in cardiac surgery. This review systematizes current data on the impact of the A1166C (rs5186) single nucleotide polymorphism of the angiotensin II type 1 receptor gene (AGTR1) on post-infarction remodeling and surgical revascularization outcomes. The molecular genetic mechanism is considered, in which the transition of adenine to cytosine disrupts the binding of microRNA-155 to the gene’s mRNA, leading to pathological overexpression of AT1R on cell membranes. Under conditions of surgical stress, carrying the mutant C allele is associated with systemic inflammation, endothelial dysfunction, accelerated myocardial fibrosis, an increased risk of graft thrombosis, and the development of atrial fibrillation. Special attention is paid to the pharmacogenetic aspect: the phenomenon of "escape"during ACE inhibitor therapy is described in carriers of the C allele, which makes the prioritized prescription of angiotensin receptor blockers (ARBs/sartans) pathogenetically justified. The clinical significance of genotyping the rs5186 locus for personalizing neurohumoral blockade and improving the long-term prognosis of patients is emphasized.

хроническая сердечная недостаточностьаортокоронарное шунтированиеген AGTR1полиморфизм А1166Сrs5186фармакогенетикаремоделирование миокардаренин-ангиотензин-альдостероновая системаchronic heart failurecoronary artery bypass grafting

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Цитата алуу

APA 7 
Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali, Умеров, С, Курбанов, Нурали, Ганиев, О, Юсупов, Ж, Курбанов, Н, Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek & Kurbanov, Nurali (2026). The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting. O‘zbekiston кardiologiyasi, 3(2), 55-62.
GOST R 7.0.5 
Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali, Умеров, С, Курбанов, Нурали, Ганиев, О, Юсупов, Ж, Курбанов, Н, Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting // O‘zbekiston кardiologiyasi. 2026. Т. 3. № 2. С. 55-62.
BibTeX 
@article{suleyman2026,
  author  = {Umerov, Suleyman and Asanov, David and Ganiyev, Otamurod and Yusupov, Jorabek and Kurbanov, Nurali and Умеров, С and Курбанов, Нурали and Ганиев, О and Юсупов, Ж and Курбанов, Н and Umerov, Suleyman and Asanov, David and Ganiyev, Otamurod and Yusupov, Jorabek and Kurbanov, Nurali},
  title   = {The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting},
  journal = {O‘zbekiston кardiologiyasi},
  year    = {2026},
  volume  = {3},
  number  = {2},
  pages   = {55-62}
}
RIS 
TY  - JOUR
AU  - Umerov, Suleyman
AU  - Asanov, David
AU  - Ganiyev, Otamurod
AU  - Yusupov, Jorabek
AU  - Kurbanov, Nurali
AU  - Умеров, С
AU  - Курбанов, Нурали
AU  - Ганиев, О
AU  - Юсупов, Ж
AU  - Курбанов, Н
AU  - Umerov, Suleyman
AU  - Asanov, David
AU  - Ganiyev, Otamurod
AU  - Yusupov, Jorabek
AU  - Kurbanov, Nurali
TI  - The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting
JO  - O‘zbekiston кardiologiyasi
PY  - 2026
VL  - 3
IS  - 2
SP  - 55
EP  - 62
ER  -