Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 6-том 1-сан (2021)

NEUROPROTECTION AS A THERAPEUTIC TARGET IN DIABETIC RETINOPATHY

Мужи-Эмилия Комилжоновна Мустафаева, Фазилат Арифовна Бахритдинова

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Аннотация

Diabetic retinopathy (DR) is considered a microcirculatory disease of the retina. However, new data are emerging that suggest that retinal neurodegeneration is an early event in the pathogenesis of DR, which may precede the development of microcirculatory disorders that occur in DR, as well as participate in them. Therefore, studying the underlying mechanisms that lead to neurodegeneration will be essential for identifying new therapeutic targets in the early stages of DR. Elevated glutamate levels, oxidative stress, overexpression of the renin-angiotensin system, and activation of glycation end-product receptors play important roles in diabetic-induced retinal neurodegeneration. Finally, the balance between neurotoxic and neuroprotective factors is critical in determining the survival of retinal neurons. In this review, we focus on neurotrophic factors already synthesized by the retina under physiological conditions, and we also discuss current neuroprotective strategies and future directions for the treatment of DR.

Диабетическая ретинопатия. Нейродегенерация. Нейропротекция. Лечение диабетической ретинопатии. Нервно-сосудистая связьDiabetic retinopathy. Neurodegeneration. Neuroprotection. Diabetic retinopathy treatment. Neurovascular connectionDiabetik retinopatiya. Neyrodejeneratsiya. Neyroprotektsiya. Diyabetik retinopatiyani davolash. Neyrovaskulyar birikma

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Цитата алуу

APA 7 
Мужи-Эмилия Комилжоновна Мустафаева & Фазилат Арифовна Бахритдинова (2021). NEUROPROTECTION AS A THERAPEUTIC TARGET IN DIABETIC RETINOPATHY. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 6(1).
GOST R 7.0.5 
Мужи-Эмилия Комилжоновна Мустафаева, Фазилат Арифовна Бахритдинова NEUROPROTECTION AS A THERAPEUTIC TARGET IN DIABETIC RETINOPATHY // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. 2021. Т. 6. № 1.
BibTeX 
@article{мустафаева2021,
  author  = {Мужи-Эмилия Комилжоновна Мустафаева and Фазилат Арифовна Бахритдинова},
  title   = {NEUROPROTECTION AS A THERAPEUTIC TARGET IN DIABETIC RETINOPATHY},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year    = {2021},
  volume  = {6},
  number  = {1}
}
RIS 
TY  - JOUR
AU  - Мужи-Эмилия Комилжоновна Мустафаева
AU  - Фазилат Арифовна Бахритдинова
TI  - NEUROPROTECTION AS A THERAPEUTIC TARGET IN DIABETIC RETINOPATHY
JO  - Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
PY  - 2021
VL  - 6
IS  - 1
ER  -