Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 6-том 1-сан (2021)
STUDY OF THE STATE OF TISSUE REMODELING IN PERSONS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DISPLASI
Гуландом Зикрияевна Шодикулова, Заррина Бахтияровна Бабамурадова, Озод Вохидович Мирзаев
Аннотация
Objective: to carry out comparative analysis of matrix metalloproteinase’s-2,9 (MMP-2, 9), tissue inhibitors of matrix metalloproteinase’s (TIMP) expression indexes and their interconnection with magnesium ions (Mg2+), glucosamine-glycans and glucuronidases activity in the blood of patients with undifferentiated connective tissue dysplasia. Material and research methods. 208 persons of them aged 15-25 (19.9±1.42) years have been studied. Depending on clinical signs and progressive complications, patients were divided into 2 groups, 1-group 97 patients with signs of external phenotypes (fens) of BTDD, 2-group 111 patients with signs of external and internal fens, with some complications. Results of researches have shown that the blood of patients with BTDD showed an increase in MMP-2 and MMP-9 and a decrease in TIMP-1. As the progression of the disease increases, the expression of MMP-2 and MMP-9 increases and the TIMP-1 decreases, compared to the data in the control group. At the same time, in patients there is a decrease in Mg 2 ions in blood. Thus, dynamics of changes of MMP-2 and MMP-9 and also TIMP-1 expression in patients with undifferentiated connective tissue dysplasia may serve as a method of estimation of progressive pathological process and prognosis of the disease.
Недифференцированная дисплазия соединительной ткани, металлопротеиназы, тканевые ингибиторы металлопротеиназ, ионы магния (Mg 2)undifferentiated connective tissue dysplasia, matrix metalloproteinase’s, inhibitors of matrix metalloproteinase’s, magnesium (Mg2 ) ionsBiriktiruvchi to'qima differentsiyalanmagan displaziyasi, metalloproteinazlar, metalloproteinazalarning to'qima ingibitorlari, magniy ionlari (Mg 2)
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