Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Том 7 № 1 (2022)
TO STUDY THE PREVALENCE OF ALLELES AND GENOTYPES OF TWO POLYMORPHIC MARKERS OF THE CYP 2C9 AND CYP2C19 GENE
АБДАШИМОВ Зафар Бахтиярович
Аннотация
The most clinically significant polymorphic markers of the CYP2C9 gene are the amino acid substitutions CYP2C9*2 (substitution in the 144 position of the polypeptide chain, leading to the substitution of the amino acid arginine for cysteine; 144Arg) and CYP2C9*3 (substitution in the 359 position of the polypeptide chain, leading to the substitution of the amino acid isoleucine for leucine; 359Leu). The genetic polymorphism of CYP 2C19 has pronounced interindividual differences. The significance of genetic polymorphism is determined when the occurrence of variant alleles is more than 1% in the population.
полиморфный маркер гена CYP 2С9, полиморфный маркер гена CYP 2С19, генетика, волонтеры, узбекская национальностьpolymorphic marker of the CYP 2C9 gene, polymorphic marker of the CYP 2C19 gene, genetics, volunteers, Uzbek nationalityCYP 2C9 генининг полиморф маркери, CYP 2C19 генининг полиморф маркери, генетика, кўнгиллилар, ўзбек миллати
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