Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Том 7 № 3 (2022)
PHOSPHOLIPID FORMATION AND LIPID PEROXIDATION OF ERYTHROCYTE MEMBRANES IN INFANTS BORN TO MOTHERS GESTOSIS WITH CHRONIC PYELONEPHRITIS
ИШКАБУЛОВА Гульчехра Джанкуразовна, ХОЛМУРАДОВА Зилола Эргашевна
Аннотация
Purpose: to study the features of the activity of blood phospholipases, the state of lipid peroxidation and the phospholipid composition of erythrocyte membranes in newborns from mothers in combination with "pure" pyelonephritis and chronic preeclampsia of pregnant women. Materials and methods: a complete clinical and laboratory examination of 69 newborns was carried out, of which 23 children were born from physiologically healthy mothers (control group), 20 children were born from mothers who had only preeclampsia during pregnancy (group 1), and 26 children ( group 2), born from mothers with 2nd and 3rd degree of preeclampsia and chronic pyelonephritis. Results: Having considered the nature of changes in lipid peroxidation, the phospholipid spectrum of the lipid bilayer of erythrocyte membranes in healthy newborns and those born from mothers with pure combined preeclampsia, it should be noted that there are the most profound changes in the structure of cytomembranes in newborns whose gestation proceeded against the background of preeclampsia, combined with chronic pyelonephritis, about as evidenced by the accumulation of lysoforms of phospholipids, the end products of lipid peroxidation. Conclusion. These data point to the need for early antioxidant and membrane-protective corrective therapy for this contingent of newborns.
пиелонефрит, гестоз, эритроцитарная оболочка, новорожденныеpyelonephritis, preeclampsia, erythrocyte membrane, newbornspielonefrit, SHPG-gestoz, eritrotsitlar membranasi, yangi tug'ilgan chaqaloqlar
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