Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali Volume 7 Issue 4 (2022)

THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450 GENES WITH GRAVES' DISEASE

Кодиров Аваз Эшмаматович, Зиядуллаев Шухрат Худойбердиевич, Ким Антонина Амуровна, Камалов Зайнитдин Сайфутдинович, Рузибакиева Малика Руслановна, Олимжонова Фарангиз Жасур Қизи

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Abstract

Objective: To study the distribution of allele and genotype frequencies of the polymorphic region G197A (rs2275913) of the IL-17A gene and A6986G (rs776746) of the CYP3A5 gene in patients with Graves' disease and establish the contribution to the development of the disease.Methods: The main group consisted of 97 patients with Graves' disease. The surveyed group consisted of individuals observed at the Department of Endocrinology of the Samarkand State Medical University. The study control group included 66 donors without thyroid pathology.Results: In this study, we studied the distribution of allele and genotype frequencies of the polymorphic variant G-197A (rs2275913) of the IL-17A gene in patients with DTG. As can be seen from our results, the risk marker for the development of DTG is the A allele and the homozygous AA genotype (12.37% and 3.03%, respectively; OR = 4.518; 95% CI: 0.977 > 4.518 > 20.899; χ2 = 4.365 (p =0.03669)).Conclusions. Thus, a significant increase in the A197 allele confirms the involvement of systemic inflammatory reactions in the pathogenesis of such a disease as diffuse toxic goiter.

Диффузный токсический зоб, полиморфизм, иммунной системы, генDiffuse toxic goiter, polymorphism, immune systemDiffuz toksik buqoq, polimorfizm, immune tizim, gen

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APA 7 
Кодиров Аваз Эшмаматович, Зиядуллаев Шухрат Худойбердиевич, Ким Антонина Амуровна, Камалов Зайнитдин Сайфутдинович, Рузибакиева Малика Руслановна & Олимжонова Фарангиз Жасур Қизи (2022). THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450  GENES WITH GRAVES' DISEASE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 7(4).
GOST R 7.0.5 
Кодиров Аваз Эшмаматович, Зиядуллаев Шухрат Худойбердиевич, Ким Антонина Амуровна, Камалов Зайнитдин Сайфутдинович, Рузибакиева Малика Руслановна, Олимжонова Фарангиз Жасур Қизи THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450  GENES WITH GRAVES' DISEASE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. 2022. Т. 7. № 4.
BibTeX 
@article{эшмаматович2022,
  author  = {Кодиров Аваз Эшмаматович and Зиядуллаев Шухрат Худойбердиевич and Ким Антонина Амуровна and Камалов Зайнитдин Сайфутдинович and Рузибакиева Малика Руслановна and Олимжонова Фарангиз Жасур Қизи},
  title   = {THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450  GENES WITH GRAVES' DISEASE},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year    = {2022},
  volume  = {7},
  number  = {4}
}
RIS 
TY  - JOUR
AU  - Кодиров Аваз Эшмаматович
AU  - Зиядуллаев Шухрат Худойбердиевич
AU  - Ким Антонина Амуровна
AU  - Камалов Зайнитдин Сайфутдинович
AU  - Рузибакиева Малика Руслановна
AU  - Олимжонова Фарангиз Жасур Қизи
TI  - THE ROLE OF POLYMORPHIC VARIANTS OF IL17A AND CYTOCHROME P450  GENES WITH GRAVES' DISEASE
JO  - Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
PY  - 2022
VL  - 7
IS  - 4
ER  -