Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 8-tom 1-san (2023)
EVALUATION OF THE EFFECTIVENESS OF A TUMOR NECROSIS FACTOR INHIBITOR IN THE TREATMENT OF ANKYLOSING SPONDYLITIS
МУХАММАДИЕВА Севара Муродуллаевна, НАБИЕВА Дилдорахон Абдумаликовна, ЗИЯЕВА Феруза Камаллидиновна, МИРХАМИДОВ Мирзиёд Восилжонович, ШИРАНОВА Шахноза Абдиназаровна
Annotaciya
This article is devoted to the effectiveness of treating ankylosing spondylitis (AS), a chronic inflammatory disease of the musculoskeletal system. The study included 53 patients with active AS (BASDAI activity index >4) and failure of standard therapy, which included the TNF-a inhibitor infliximab (INF) at a dose of 3-5 mg/kg intravenously for 0, 2, 6 weeks and next every 8 weeks. In patients treated with INF, a positive clinical effect was achieved by indicators BASDAI and BASMI scores, as well as a remarkable positive result in dynamics vertebral mobility index and BASFI score. Tolerability of INF patients was satisfactory.
анкилозирующий спондилоартрит, диагностика, лечение, ингибиторы ФНO-α, инфликсимабанкилозловчи спондилоартрит, диагностика, даволаш, ЎНО-α ингибиторлари, инфликсимаб
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