Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 8-tom 2-san (2023)
THE SIGNIFICANCE OF AUTOANTIBODIES IN THE PATHOGENESIS OF SYSTEMIC SCLEROSIS (LITERATURE REVIEW)
ЗАРИПОВ Санжарбек Истамович, АХМЕДОВ Халмурад Садуллаевич, АБДУРАХМАНОВА Наргиза Мирза-Бахтиярхоновна
Annotaciya
Systemic sclerosis is a progressive chronic autoimmune rheumatic disease with high morbidity and mortality. Systemic sclerosis a multi-organ disease that affects organs such as the skin, lungs, digestive system, heart, musculoskeletal system, kidneys, causing severe pain and disability, disability and death of patients. The main marker of an abnormal immune response is circulating autoantibodies, which are found in more than 95% of patients with systemic sclerosis. It is important to study the clinical, immunological, diagnostic and prognostic significance of autoantibodies, especially antifibrillary antibodies produced against the fibrillarin protein.
системная склеродермия, антинуклеарные антитела (АНА), фибрилларин, антифибриллярные антитела (АФА), феномен Рейно, модифицированная кожная шкала Роднана (mRSS)systemic sclerosis, antinuclear antibodies (ANA), fibrillarin, antifibrillary antibodies (AFA), Raynaud's phenomenon, modified Rodnan skin scale (mRSS)тизимли склеродермия, антинуклеар антитаналар (АНА), фибрилларин, антифибриллар антитаналар (АФА), Рейно феномени, модификацияланган Роднан тери шкаласи (mRSS)
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