Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 8-tom 4-san (2023)
SIGNIFICANCE OF UROMODULIN IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC KIDNEY DISEASE.
ТАШКЕНБАЕВА Элеонора Негматовна, ЕСАНКУЛОВ Мухаммад Олимович
Annotaciya
Uromodulin (Tamm-Horsfall protein) is produced in the kidney by cells of the thick ascending limb and distal tubule. Recent genetic studies suggest a role of uromodulin in chronic kidney disease. Mutations in the UMOD gene cause uromodulin storage disease. They code for amino acid substitutions that lead to misfolding of the molecule and its retention in the endoplasmic reticulum. Single nucleotide polymorphisms in the region of the UMOD gene have been shown to be associated with chronic kidney disease and reduced glomerular filtration rate. These polymorphisms affect uromodulin concentration in the urine, and lower genetically determined urinary uromodulin concentrations seem to protect against renal disease. Chronic kidney disease is associated with higher serum levels of uromodulin. From animal experiments and human studies it is hypothesized that uromodulin entering the renal interstitium either by basolateral secretion or urinary back-leakage in damaged tubuli interacts with and stimulates cells of the immune system and thereby causes inflammation and progression of chronic kidney disease.
уромодулин, белок Тамма-Хорсфалла, хроническая болезнь почек, генетика, мочевыводящие путиUromodulin, Tamm-Horsfall protein, Chronic kidney disease, genetic, urinaryUromodulin, Tamm-Horsfall oqsili, Surunkali buyrak kasalligi, genetik, siydik
Metadata derekkózi: jurnal OAI-PMH arxivi · Sindex tolıq mátindi saqlamaydı, derekkózge silteme beredi.