Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 8-том 5-нөмір (2023)
INFLUENCE OF HIGH BODY MASS INDEX ON SENSITIVITY TO NEOADJUVANT CHEMOTHERAPY OF TUMOR IN BREAST CANCER
АЛИМХОДЖАЕВА Лола Телмановна, ЗАКИРОВА Лола Тулкуновна, МИРЗАЕВА Матлюба Акбарали кизи, ИРМАТОВА Гузал Махаматжановна
Аңдатпа
To evaluate the effect of body mass index on tumor response to chemotherapy in breast cancer. Background. Obesity is not only one of the risk factors leading to breast cancer but how obesity accompanies cancer is crucial for evaluating the effects of the disease. This article examines the role of obesity in the occurrence and course of breast cancer in women and their involvement in tumor development and progression. Material and methods. The retrospective study was conducted on 24 patients with early-stage breast cancer women who accepted neoadjuvant chemotherapy in the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology. The patients were divided into two groups depending on the BMI of women: the first group included BMI≤30 (control group), and the second group consisted of BMI≥30 women. Results. In patients with a high body mass index, the indicators indicate that, regardless of the number of NCHT courses due to obesity, tumor sensitivity is lower than in patients with an average body mass index (p<0.01). Conclusion. A decrease in the body mass index in patients with breast cancer leads to an improvement in the disease outcomes and a reduction in the resistantce of the tumor to chemotherapy.
рак молочной железы, индекс массы тела, неоадъювантная химиотерапия, фертильный период, резистентность.breast cancer, body mass index, neoadjuvant chemotherapy, premenopausal period, resistant: ko’krak bezi saratoni, tana vazni indeksi, neoadyuvant kimyoterapiya, fertil davr, rezistentlik
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