Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali 8-tom 6-san (2023)

OUR EXPERIENCE OF BILATERAL ADRENALECTOMY FOR ITZENKO-CUSHING SYNDROME

БЕРКИНОВ Улугбек Базарбаевич, САХИБАЕВ Дилшод Парпижалилович, ОМОНОВ Жамолиддин Шарофиддинович, ЖУРАЕВА Мардона Меликузиевна

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Purpose: to analyze the results of bilateral adrenalectomy for Itsenko-Cushing syndrome. Material and methods. From the analyzed 16 cases of bilateral adrenalectomy (AE), in 14 it was performed in stages (in 11 cases with Itsenko-Cushing's disease after unsuccessful transsphenoidal adenomectomy (TAE), in 2 - with ectopic Cushing's syndrome (ECS), in 1 - with bilateral corticosteroma), and in two cases – simultaneously (in 2 cases with bilateral corticosteroma). The age of the patients was on average 30.14±4.13 (20-38) years, the ratio of men to women was 1:1.7. in 4 cases, AE was performed transabdominally, and in 28 cases, retroperitoneoscopically. Results. The median follow-up period was 35.5 months. After AE, the vast majority (75%) of patients lost excess weight and achieved a BMI <25 (P < 0.001). A statistically significant improvement was also observed in arterial hypertension (from 93.75% to 50%) (P < 0.005). Before the operation, 56.25% suffered from diabetes mellitus, and after the operation - 18.5%. Acute adrenal insufficiency developed in 25% of patients. Death during the observation period was observed in 18.75% of cases. Conclusion. Bilateral AE is an effective method for treating manifestations of hypercortisolism in patients with SIC. It provides good palliative treatment for DIC with failed TAE and ESIC. Most patients have good survival and good quality of life. Mortality in the postoperative period is directly related to the severity of complications that develop in the preoperative period.

синдром Иценко-Кушинга, двусторонняя адреналэктомия, транссфеноидальная аденомэктомия, эктопический синдром Кушинга, двусторонняя кортикостеромаItsenko-Cushing syndrome, bilateral adrenalectomy, transsphenoidal adenomectomy, ectopic Cushing's syndrome, bilateral corticosteromaItsenko-Kushing sindromi, ikki tomonlama adrenalektomiya, transsfenoidal adenomektomiya, ektopik Kushing sindromi, ikki tomonlama kortikosteroma

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APA 7 
БЕРКИНОВ Улугбек Базарбаевич, САХИБАЕВ Дилшод Парпижалилович, ОМОНОВ Жамолиддин Шарофиддинович & ЖУРАЕВА Мардона Меликузиевна (2023). OUR EXPERIENCE OF BILATERAL ADRENALECTOMY FOR ITZENKO-CUSHING SYNDROME. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 8(6).
GOST R 7.0.5 
БЕРКИНОВ Улугбек Базарбаевич, САХИБАЕВ Дилшод Парпижалилович, ОМОНОВ Жамолиддин Шарофиддинович, ЖУРАЕВА Мардона Меликузиевна OUR EXPERIENCE OF BILATERAL ADRENALECTOMY FOR ITZENKO-CUSHING SYNDROME // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. 2023. Т. 8. № 6.
BibTeX 
@article{базарбаевич2023,
  author  = {БЕРКИНОВ Улугбек Базарбаевич and САХИБАЕВ Дилшод Парпижалилович and ОМОНОВ Жамолиддин Шарофиддинович and ЖУРАЕВА Мардона Меликузиевна},
  title   = {OUR EXPERIENCE OF BILATERAL ADRENALECTOMY FOR ITZENKO-CUSHING SYNDROME},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year    = {2023},
  volume  = {8},
  number  = {6}
}
RIS 
TY  - JOUR
AU  - БЕРКИНОВ Улугбек Базарбаевич
AU  - САХИБАЕВ Дилшод Парпижалилович
AU  - ОМОНОВ Жамолиддин Шарофиддинович
AU  - ЖУРАЕВА Мардона Меликузиевна
TI  - OUR EXPERIENCE OF BILATERAL ADRENALECTOMY FOR ITZENKO-CUSHING SYNDROME
JO  - Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
PY  - 2023
VL  - 8
IS  - 6
ER  -